ArticleIrish journal of medical science2011
The incidence and clinical correlates of lithium toxicity: a retrospective review.
Article in Irish journal of medical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Lithium Toxicity in Older Adults: a Systematic Review of Case Reports.Clinical drug investigation · 2018Pooled it
- Drug-induced cerebellar ataxia: a systematic review.CNS drugs · 2014Pooled it
- A case report of persistent cerebellar dysfunction following acute lithium toxicity.BMC neurology · 2026Article
- Tips and tricks in tremor treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- General practitioners' perceptions of pharmacists working in general practice: a qualitative interview study.Family practice · 2023Article
- The Gilded Clot: Review of Metal-Modulated Platelet Activation, Coagulation, and Fibrinolysis.International journal of molecular sciences · 2023Review
- Hemodialysis Treatment for Patients with Lithium Poisoning.International journal of environmental research and public health · 2022Article
- The clinical characteristics and correlates of lithium toxicity in a tertiary referral centre.Irish journal of medical science · 2019Article
- Outcomes of patient education practices to optimize the safe use of lithium: A literature review.The mental health clinician · 2018Article
- Lithium intoxication: Incidence, clinical course and renal function - a population-based retrospective cohort study.Journal of psychopharmacology (Oxford, England) · 2016Article
- Stratifying Risk for Renal Insufficiency Among Lithium-Treated Patients: An Electronic Health Record Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Effect of Adenine on Clozapine-induced Neutropenia in Patients with Schizophrenia: A Preliminary Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2015Article
- Chronic kidney disease in lithium-treated older adults: a review of epidemiology, mechanisms, and implications for the treatment of late-life mood disorders.Drugs & aging · 2015Review
- Acute renal failure induced by markedly decreased appetite secondary to a depressive episode after discontinuation of long-term lithium therapy in an elderly patient with bipolar disorder.BMJ case reports · 2014Article
- Substance of abuse and movement disorders: complex interactions and comorbidities.Current drug abuse reviews · 2012Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLithium is a commonly prescribed pharmacological treatment for mood disorders. It is associated with a number of side effects and potentially serious toxicity. To date, there is little data from Irish samples on the subject of Lithium toxicity.
aimTo examine the incidence and clinical correlates of lithium toxicity in Cork, Ireland.
resultsOur study identified 130 cases of biochemical lithium toxicity over 5 years, with an incidence rate of approximately 5.4 cases per 100,000 per year. Mean toxic lithium level was 2.16 mmol/L ±SD 0.87 mmol/L. Of these, 36% cases were reviewed medically in the general hospital at the time of toxicity. A number of issues in relation to lithium toxicity were identified. Neurological symptoms were common, including tremor, confusion, ataxia, drowsiness. However, only 4.2% patients were reviewed by a neurologist while in hospital. Medications that interact with lithium were found in 50% cases, with significant polypharmacy in 15%. The psychiatric services were involved in patient care in 76% cases, and 85% patients presenting with toxicity were reviewed by a psychiatrist. Rates of admission to hospital and haemodialysis were 70 and 11%, respectively.
conclusionImprovements in the standards of care in relation to lithium prescribing are required.
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