SynthesisDiabetes2011
Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children.
Synthesis in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Meta-analyses of the association of G6PC2 allele variants with elevated fasting glucose and type 2 diabetes.PloS one · 2017Pooled it
- Meta-analysis of genome-wide association study of homeostasis model assessment β cell function and insulin resistance in an East Asian population and the European results.Molecular genetics and genomics : MGG · 2014Pooled it
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.Nature genetics · 2012Pooled it
- Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.Nature genetics · 2011Pooled it
- Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children.BMC medical genetics · 2012Trial
- Nardilysin regulatesBiochemistry and biophysics reports · 2026Article
- Nature vs nurture of glucose homeostasis trajectories in children from the ALSPAC study.Diabetologia · 2026Article
- Bridging pancreatic and hepatic development: overlapping genes and their role in diabetes.Cellular & molecular biology letters · 2025Review
- Modeling Genetic Risk of β-Cell Dysfunction in Human Induced Pluripotent Stem Cells From Patients Carrying the MTNR1B Risk Variant.Journal of pineal research · 2025Article
- Article
- In Utero Exposure to Maternal Hyperglycemia and Offspring Type 2 Diabetes Genetic Risk Score Are Independently Associated With Risk of Impaired Glucose Tolerance in Youth.Diabetes care · 2025Article
- Interaction Between Dietary Fiber Intake andGenes · 2025Article
- DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits.Nature communications · 2024Article
- Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus.Acta pharmaceutica Sinica. B · 2024Review
- Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Dietary Sugar Research in Preschoolers: Methodological, Genetic, and Cardiometabolic Considerations.Reviews in cardiovascular medicine · 2023Review
- The role of GLUT2 in glucose metabolism in multiple organs and tissues.Molecular biology reports · 2023Review
- Enhancing circadian rhythms-the circadian MEGA bundle as novel approach to treat critical illness.Annals of translational medicine · 2023Review
- Identification of genetic variants related to metabolic syndrome by next-generation sequencing.Diabetology & metabolic syndrome · 2022Article
- The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road Ahead.The Journal of pediatrics · 2022Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 13 institutions in 7 countries.
Funding
Abstract
objectiveTo investigate whether associations of common genetic variants recently identified for fasting glucose or insulin levels in nondiabetic adults are detectable in healthy children and adolescents. RESEARCH DESIGN AND
methodsA total of 16 single nucleotide polymorphisms (SNPs) associated with fasting glucose were genotyped in six studies of children and adolescents of European origin, including over 6,000 boys and girls aged 9-16 years. We performed meta-analyses to test associations of individual SNPs and a weighted risk score of the 16 loci with fasting glucose.
resultsNine loci were associated with glucose levels in healthy children and adolescents, with four of these associations reported in previous studies and five reported here for the first time (GLIS3, PROX1, SLC2A2, ADCY5, and CRY2). Effect sizes were similar to those in adults, suggesting age-independent effects of these fasting glucose loci. Children and adolescents carrying glucose-raising alleles of G6PC2, MTNR1B, GCK, and GLIS3 also showed reduced β-cell function, as indicated by homeostasis model assessment of β-cell function. Analysis using a weighted risk score showed an increase [β (95% CI)] in fasting glucose level of 0.026 mmol/L (0.021-0.031) for each unit increase in the score.
conclusionsNovel fasting glucose loci identified in genome-wide association studies of adults are associated with altered fasting glucose levels in healthy children and adolescents with effect sizes comparable to adults. In nondiabetic adults, fasting glucose changes little over time, and our results suggest that age-independent effects of fasting glucose loci contribute to long-term interindividual differences in glucose levels from childhood onwards.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.