Evidence map›Paper›PMID 21515664›Full record

ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2012

Novel measurements of mammary stem cells in human umbilical cord blood as prospective predictors of breast cancer susceptibility in later life.

L Qiu, H P Low, C-I Chang, W C Strohsnitter, M Anderson, K Edmiston, H-O Adami, A Ekbom, P Hall, P Lagiou and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Prenatal Maternal Physical Activity and Stem Cells in Umbilical Cord Blood.Medicine and science in sports and exercise · 2016
    Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

L QiuDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester.
H P LowDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester.
C-I ChangDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester.
W C StrohsnitterDepartment of Obstetrics and Gynecology, Tufts Medical Center, Boston.
M AndersonDivision of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and University of Massachusetts Memorial Health Care, Worcester.
K EdmistonDivision of Hematology/Oncology, Department of Medicine, University of Massachusetts Medical School and University of Massachusetts Memorial Health Care, Worcester.
H-O AdamiDepartment of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm.
A EkbomUnit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.
P HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm.
P LagiouDepartment of Epidemiology, Harvard School of Public Health, Boston, USA; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.
D TrichopoulosDepartment of Epidemiology, Harvard School of Public Health, Boston, USA.
C-C HsiehDepartment of Cancer Biology, University of Massachusetts Medical School, Worcester. Electronic address: chung-cheng.hsieh@umassmed.edu.
University of Massachusetts Chan Medical School · USHarvard University · USBoston University · USKarolinska Institutet · SEKarolinska University Hospital · SETufts Medical Center · US

Funding

Stem Cells and Perinatal Factors for Breast Cancer RiskR01CA090902 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HSIEH, CHUNG-CHENG · 2002 to 2011
$3.3M
NCI NIH HHS CA090902
6 · The paper itself

Abstract

backgroundThe size of the breast stem-cell pool could underlie the intrauterine roots of breast cancer. We studied whether breast stem cells exist in umbilical cord blood and if they correlate with hematopoietic stem-cell measurements that have been positively associated with perinatal risk factors for breast cancer. SUBJECTS AND

methodsWe isolated mononuclear cells from umbilical cord blood of 170 singleton full-term pregnancies and determined, by reverse transcription polymerase chain reaction, the presence of genes of putative breast epithelial stem-cell/progenitor markers [including epithelial cell adhesion molecule (EpCAM), CD49f (α6-integrin), CD117 (c-kit receptor), CD24, and CD29 (β1-integrin)]. By immunocytochemistry, we colocalized protein expressions of EpCAM+CD49f+, CD49f+CD24+, and CD24+CD29+. We correlated concentrations of putative breast stem-cell/progenitor subpopulations, quantified by flow cytometry, with concentrations of hematopoietic stem cells.

resultsMammary stem-cell phenotypes were identified in umbilical cord blood. The measured EpCAM+ subpopulation was positively correlated with concentrations of CD34+ and CD34+CD38- hematopoietic stem cells (both P=0.006). Additionally, EpCAM+CD49f+ and CD49f+CD24+ subpopulations were positively correlated to the CD34+ cells (P=0.03 and 0.008, respectively).

conclusionThe positive association between measurable breast and hematopoietic stem cells in human umbilical cord blood suggests plausible mechanisms for a prenatal influence on breast cancer risk.

Indexed as

Antigens, NeoplasmBiomarkers, TumorBreastBreast NeoplasmsCD24 AntigenCell Adhesion MoleculesCell SeparationDisease SusceptibilityEpithelial Cell Adhesion MoleculeFemaleFetal BloodFlow CytometryHematopoietic Stem CellsHumansImmunohistochemistryIntegrin alpha6Antigens, NeoplasmBiomarkers, TumorCD24 AntigenCell Adhesion MoleculesEPCAM protein, humanEpithelial Cell Adhesion MoleculeIntegrin alpha6Integrin beta1Proto-Oncogene Proteins c-kit

Identifiers

PMID21515664
PMCPMC3276324
OpenAlexW2125789030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.