ReviewThe Journal of steroid biochemistry and molecular biology2011
Disruption of androgen receptor signaling in males by environmental chemicals.
Review in The Journal of steroid biochemistry and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 167 citations in OpenAlex.
- An updated systematic review on the possible effect of nonylphenol on male fertility.Environmental science and pollution research international · 2017Pooled it
- Review
- Neonicotinoids and the Androgen Receptor: Structural Dynamics and Potential Signaling Disruption.Biology · 2026Article
- BPA-induced differential methylation of the androgen receptor promoter CpG island in medaka germline and somatic cells.Environmental epigenetics · 2026Article
- Risk of prostate cancer associated with long-term air pollution exposure: a nationwide cohort study in Taiwan.BMC public health · 2025Article
- The effect of an organophosphorus pesticide, chlorpyrifos (from different local sources), on the testicular tissue in adult male albino rats.Environmental analysis, health and toxicology · 2025Article
- Prediction of Pharmacokinetics of Valeric Acid: Alternative Tool to Minimize Animal Studies.Current drug metabolism · 2025Article
- New insights on testicular cancer prevalence with novel diagnostic biomarkers and therapeutic approaches.Cancer reports (Hoboken, N.J.) · 2024Review
- Developmental programming: Impact of preconceptional and gestational exposure to a real-life environmental chemical mixture on maternal steroid, cytokine and oxidative stress milieus in sheep.The Science of the total environment · 2023Article
- Computational pharmacology and computational chemistry of 4-hydroxyisoleucine: Physicochemical, pharmacokinetic, and DFT-based approaches.Frontiers in chemistry · 2023Article
- Article
- Discovery of Novel HIV Protease Inhibitors Using Modern Computational Techniques.International journal of molecular sciences · 2022Article
- Flutamide treatment reveals a relationship between steroidogenic activity of Leydig cells and ultrastructure of their mitochondria.Scientific reports · 2021Article
- An approach to classifying occupational exposures to endocrine disrupting chemicals by sex hormone function using an expert judgment process.Journal of exposure science & environmental epidemiology · 2021Review
- Combined Naïve Bayesian, Chemical Fingerprints and Molecular Docking Classifiers to Model and Predict Androgen Receptor Binding Data for Environmentally- and Health-Sensitive Substances.International journal of molecular sciences · 2021Article
- Review
- Evaluation of a multiplexed, multispecies nuclear receptor assay for chemical hazard assessment.Toxicology in vitro : an international journal published in association with BIBRA · 2021Article
- Predicting the Activation of the Androgen Receptor by Mixtures of Ligands Using Generalized Concentration Addition.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Article
- Molecules targeting the androgen receptor (AR) signaling axis beyond the AR-Ligand binding domain.Medicinal research reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Androgen-disruptors are environmental chemicals in that interfere with the biosynthesis, metabolism or action of endogenous androgens resulting in a deflection from normal male developmental programming and reproductive tract growth and function. Since male sexual differentiation is entirely androgen-dependent, it is highly susceptible to androgen-disruptors. Animal models and epidemiological evidence link exposure to androgen disrupting chemicals with reduced sperm counts, increased infertility, testicular dysgenesis syndrome, and testicular and prostate cancers. Further, there appears to be increased sensitivity to these agents during critical developmental windows when male differentiation is at its peak. A variety of in vitro and in silico approaches have been used to identify broad classes of androgen disrupting molecules that include organochlorinated pesticides, industrial chemicals, and plasticizers with capacity to ligand the androgen receptor. The vast majority of these synthetic molecules act as anti-androgens. This review will highlight the evidence for androgen disrupting chemicals that act through interference with the androgen receptor, discussing specific compounds for which there is documented in vivo evidence for male reproductive tract perturbations. This article is part of a Special Issue entitled 'Endocrine disruptors'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.