ArticleMicrovascular research2011
Immortalized CNS pericytes are quiescent smooth muscle actin-negative and pluripotent.
Article in Microvascular research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Research advances in cochlear pericytes and hearing loss.Hearing research · 2023Review
- The Impact of Paracoccidioides spp Infection on Central Nervous System Cell Junctional Complexes.Mycopathologia · 2022Article
- Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma.Therapeutic advances in medical oncology · 2020Review
- Persistent Angiogenesis in the Autism Brain: An Immunocytochemical Study of Postmortem Cortex, Brainstem and Cerebellum.Journal of autism and developmental disorders · 2016Article
- Pericytes at the intersection between tissue regeneration and pathology.Clinical science (London, England : 1979) · 2015Review
- A role for human brain pericytes in neuroinflammation.Journal of neuroinflammation · 2014Article
- The role of pericytes in neurovascular unit remodeling in brain disorders.International journal of molecular sciences · 2014Review
- Obstructive sleep apnea and cognitive impairment: addressing the blood-brain barrier.Sleep medicine reviews · 2014Review
- Imaging pericytes and capillary diameter in brain slices and isolated retinae.Nature protocols · 2014Article
- Role of pericytes in skeletal muscle regeneration and fat accumulation.Stem cells and development · 2013Article
- Myelin repair and functional recovery mediated by neural cell transplantation in a mouse model of multiple sclerosis.Neuroscience bulletin · 2013Article
- Pharmacological inhibition of mitochondrial carbonic anhydrases protects mouse cerebral pericytes from high glucose-induced oxidative stress and apoptosis.The Journal of pharmacology and experimental therapeutics · 2013Article
- Hypoxia alters MicroRNA expression in rat cortical pericytes.MicroRNA (Shariqah, United Arab Emirates) · 2013Article
- Skeletal muscle pericyte subtypes differ in their differentiation potential.Stem cell research · 2013Article
- A novel population of α-smooth muscle actin-positive cells activated in a rat model of stroke: an analysis of the spatio-temporal distribution in response to ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Article
- A novel and simple method for culturing pericytes from mouse brain.Microvascular research · 2012Article
- Neurovascular unit: a focus on pericytes.Molecular neurobiology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Despite their identification more than 100 years ago by the French scientist Charles-Marie Benjamin Rouget, microvascular pericytes have proven difficult to functionally characterize, due in part to their relatively low numbers and the lack of specific cell markers. However, recent progress is beginning to shed light on the diverse biological functions of these cells. Pericytes are thought to be involved in regulating vascular homeostasis and hemostasis as well as serving as a local source of adult stem cells. To further define the properties of these intriguing cells, we have isolated pericytes from transgenic mice (Immortomouse®) harboring a temperature-sensitive mutant of the SV40 virus target T-gene. This Immortopericyte (IMP) conditional cell line is stable for long periods of time and, at 33°C in the presence of interferon gamma, does not differentiate. Under these conditions IMPs are alpha muscle actin-negative and exhibit a pluripotent phenotype, but can be induced to differentiate along both mesenchymal and neuronal lineages at 37°C. Alternatively, differentiation of wild type pericytes and IMPs can be induced directly from capillaries in culture. Finally, the addition of endothelial cells to purified IMP cultures augments their rate of self-renewal and differentiation, possibly in a cell-to-cell contact dependent manner.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.