Evidence map›Paper›PMID 21515167›Full record

ArticleBiomaterials2011

Evolving the use of peptides as components of biomaterials.

Joel H Collier, Tatiana Segura

Abstract read
In one paragraph

Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Article
  2. Peptide-Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Review
  4. Building like a Coral-Parallelized, Multiscale Biofabrication.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  5. Antigen-conjugated scaffolds enable sustained delivery of antigen and enrichment of antigen-specific T-cells.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  6. Review
  7. Article
  8. Extracellular-Matrix-Mimetic Hydrogels by Using Nanomaterials.International journal of molecular sciences · 2025
    Review
  9. Engineered Protein Hydrogels as Biomimetic Cellular Scaffolds.Advanced materials (Deerfield Beach, Fla.) · 2024
    Review
  10. Article
  11. Review
  12. Scaffolds for Dentin-Pulp Complex Regeneration.Medicina (Kaunas, Lithuania) · 2023
    Review
  13. Functionalization ofBioactive materials · 2023
    Article
  14. Review
  15. Article
  16. Peptidomics.Nature reviews. Methods primers · 2023
    Article
  17. Article
  18. Article
  19. Review
  20. Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joel H CollierDepartment of Surgery, University of Chicago, Chicago, IL 60637, USA. collier@uchicago.edu
Tatiana Segura

Funding

Modular Self-Assembled Coatings for BiomaterialsR01EB009701 · NIBIB · UNIVERSITY OF CHICAGO · PI COLLIER, JOEL H · 2009 to 2021
$4.3M
NIBIB NIH HHS R01 EB009701
6 · The paper itself

Abstract

This manuscript is part of a debate on the statement that "the use of short synthetic adhesion peptides, like RGD, is the best approach in the design of biomaterials that guide cell behavior for regenerative medicine and tissue engineering". We take the position that although there are some acknowledged disadvantages of using short peptide ligands within biomaterials, it is not necessary to discard the notion of using peptides within biomaterials entirely, but rather to reinvent and evolve their use. Peptides possess advantageous chemical definition, access to non-native chemistries, amenability to de novo design, and applicability within parallel approaches. Biomaterials development programs that require such aspects may benefit from a peptide-based strategy.

Indexed as

AnimalsBiocompatible MaterialsCell AdhesionModels, MolecularOligopeptidesPeptidesProtein ConformationRegenerative MedicineTissue Engineeringarginyl-glycyl-aspartic acidBiocompatible MaterialsOligopeptidesPeptides

Identifiers

PMID21515167
PMCPMC3389831

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.