ArticleThe American journal of pathology2011
A murine model of phosphate nephropathy.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The impact of dietary phosphorus supplementation on postprandial metabolic outcomes: a systematic review.Journal of nutritional science · 2026Pooled it
- Next-generation diabetes diagnostics: spectrochemical staging of red blood cells using vibrational spectroscopy.Journal of advanced research · 2026Article
- Dietary phosphorus intake and its association with metabolic syndrome and its components: a cross-sectional analysis of the UK national diet and nutrition survey (NDNS).European journal of nutrition · 2026Article
- A Meta-Analysis on Quantitative Calcium, Phosphorus and Magnesium Metabolism in Horses and Ponies.Animals : an open access journal from MDPI · 2024Review
- Renal transcriptome analysis of uninephrectomized db/db mice identified a mechanism for the transition to severe diabetic nephropathy.Experimental animals · 2024Article
- Fibroblast Growth Factor 23 and Muscle Wasting: A Metabolic Point of View.Kidney international reports · 2023Review
- Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases.American journal of physiology. Lung cellular and molecular physiology · 2022Review
- PiT2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in OVX-induced osteoporosis.Frontiers in endocrinology · 2022Article
- The Source Matters-Effects of High Phosphate Intake from Eight Different Sources in Dogs.Animals : an open access journal from MDPI · 2021Article
- The Role of Phosphate in Alcohol-Induced Experimental Pancreatitis.Gastroenterology · 2021Article
- Novel insights into the pathological mechanisms of metabolic related dyslipidemia.Molecular biology reports · 2021Review
- Effects of dietary phosphates from organic and inorganic sources on parameters of phosphorus homeostasis in healthy adult dogs.PloS one · 2021Article
- Emerging functions of adipokines in linking the development of obesity and cardiovascular diseases.Molecular biology reports · 2020Review
- Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse.Environmental science & technology · 2019Article
- Sustained Klotho delivery reduces serum phosphate in a model of diabetic nephropathy.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- MicroRNA-142-3p improves vascular relaxation in uremia.Atherosclerosis · 2019Article
- High phosphate diet suppresses lipogenesis in white adipose tissue.Journal of clinical biochemistry and nutrition · 2018Article
- Autophagy Protects From Uremic Vascular Media Calcification.Frontiers in immunology · 2018Article
- A New Murine Model of Chronic Kidney Disease-Mineral and Bone Disorder.International journal of endocrinology · 2017Article
- Phosphorus Supplementation Recovers the Blunted Diet-Induced Thermogenesis of Overweight and Obese Adults: A Pilot Study.Nutrients · 2016Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
We established a murine model of phosphate nephropathy with secondary hyperparathyroidism. db/db mice, which develop obesity and type 2 diabetes mellitus, were uninephrectomized at the age of 6 weeks and were fed either standard chow or a phosphorus-rich diet during the next 8 weeks. Thereafter, renal cryosections showed abundant tubular casts with a strong histochemical von Kossa reaction in all db/db mice on the phosphorus-rich diet but none in the controls. X-ray diffraction and Raman spectroscopy proved that these tubular casts consist mostly of hydroxyapatite Ca₅(PO₄)₃(OH). These intraluminal precipitations were located in distal tubuli and collecting ducts and were associated with degenerative tubular changes and peritubular infiltration of T cells and macrophages. In line, kidneys of db/db mice on the phosphorus-rich diet displayed significantly increased mRNA expression of the T(H)1 cytokines interferon γ, IL-6, and tumor necrosis factor α. In addition, mice developed signs of secondary hyperparathyroidism as shown by elevated serum phosphate, decreased serum calcium, and increased parathyroid hormone, osteopontin, and fibroblast growth factor 23 levels. db/db mice on the phosphorus-rich diet also presented with significantly lower body weight, lower homeostasis model assessment of insulin resistance index, and hypertrophic cardiomyopathy. Thus, we provide a murine model of phosphate nephropathy and secondary hyperparathyroidism, which can be used for future pharmacologic and pathophysiologic studies to analyze the effect of hyperphosphatemia on renal, metabolic, and cardiovascular phenotypes.
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