ArticleSeminars in cancer biology2011
Fractal analysis in a systems biology approach to cancer.
Article in Seminars in cancer biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- GPCR-Mediated Cell Intelligence: A Potential Mechanism for Survival and Long-Term Health.Current issues in molecular biology · 2026Review
- Delving into quasi-periodic type optical solitons in fully nonlinear complex structured perturbed Gerdjikov-Ivanov equation.Scientific reports · 2025Article
- Combination of optical coherence tomography-derived shape and texture features are associated with development of sub-foveal geographic atrophy in dry AMD.Scientific reports · 2024Article
- Development, Application and Utility of a Machine Learning Approach for Melanoma and Non-Melanoma Lesion Classification Using Counting Box Fractal Dimension.Diagnostics (Basel, Switzerland) · 2024Article
- The Morphology of Brain Neurons: The Box-Counting Method in the Quantitative Analysis of 2D Images.Advances in neurobiology · 2024Article
- Novel Fractal-Based Sub-RPE Compartment OCT Radiomics Biomarkers Are Associated With Subfoveal Geographic Atrophy in Dry AMD.IEEE transactions on bio-medical engineering · 2023Article
- ComsystanJ: A collection of Fiji/ImageJ2 plugins for nonlinear and complexity analysis in 1D, 2D and 3D.PloS one · 2023Article
- Automated assessment of breast margins in deep ultraviolet fluorescence images using texture analysis.Biomedical optics express · 2022Article
- Analysis of Dormancy-Associated Transcriptional Networks Reveals a Shared Quiescence Signature in Lung and Colorectal Cancer.International journal of molecular sciences · 2022Article
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- Fractal Pennes and Cattaneo-Vernotte bioheat equations from product-like fractal geometry and their implications on cells in the presence of tumour growth.Journal of the Royal Society, Interface · 2021Article
- Machine Learning-Derived Fractal Features of Shape and Texture of the Left Atrium and Pulmonary Veins From Cardiac Computed Tomography Scans Are Associated With Risk of Recurrence of Atrial Fibrillation Postablation.Circulation. Arrhythmia and electrophysiology · 2021Article
- Phylostratic Shift of Whole-Genome Duplications in Normal Mammalian Tissues towards Unicellularity Is Driven by Developmental Bivalent Genes and Reveals a Link to Cancer.International journal of molecular sciences · 2020Article
- New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory.Acta cirurgica brasileira · 2020Article
- Atrial Rotor Dynamics Under Complex Fractional Order Diffusion.Frontiers in physiology · 2018Article
- Box-Counting Method of 2D Neuronal Image: Method Modification and Quantitative Analysis Demonstrated on Images from the Monkey and Human Brain.Computational and mathematical methods in medicine · 2017Article
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- In search of principles for a Theory of Organisms.Journal of biosciences · 2015Article
- Fractal dimension analysis of malignant and benign endobronchial ultrasound nodes.BMC medical imaging · 2014Article
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Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Cancer is a highly complex disease due to the disruption of tissue architecture. Thus, tissues, and not individual cells, are the proper level of observation for the study of carcinogenesis. This paradigm shift from a reductionist approach to a systems biology approach is long overdue. Indeed, cell phenotypes are emergent modes arising through collective non-linear interactions among different cellular and microenvironmental components, generally described by "phase space diagrams", where stable states (attractors) are embedded into a landscape model. Within this framework, cell states and cell transitions are generally conceived as mainly specified by gene-regulatory networks. However, the system's dynamics is not reducible to the integrated functioning of the genome-proteome network alone; the epithelia-stroma interacting system must be taken into consideration in order to give a more comprehensive picture. Given that cell shape represents the spatial geometric configuration acquired as a result of the integrated set of cellular and environmental cues, we posit that fractal-shape parameters represent "omics" descriptors of the epithelium-stroma system. Within this framework, function appears to follow form, and not the other way around.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.