Evidence map›Paper›PMID 21514143›Full record

ReviewCurrent opinion in structural biology2011

Computational approaches to RNA structure prediction, analysis, and design.

Christian Laing, Tamar Schlick

Abstract readReview
In one paragraph

Review in Current opinion in structural biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. START: A Versatile Platform for Bacterial Ligand Sensing with Programmable Performances.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  7. Universal cold RNA phase transitions.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Article
  10. RNA 3D Modeling with FARFAR2, Online.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. A Fiedler Vector Scoring Approach for Novel RNA Motif Selection.The journal of physical chemistry. B · 2021
    Article
  17. Predicting RNA Scaffolds with a Hybrid Method of Vfold3D and VfoldLA.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  18. In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Article
  20. 3dRNA: Building RNA 3D structure with improved template library.Computational and structural biotechnology journal · 2020
    Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christian LaingDepartment of Chemistry, Courant Institute of Mathematical Sciences, New York University, 251 Mercer Street, New York, NY 10012, USA.
Tamar Schlick

Funding

Modeling RNA Tertiary Structure Folding by a Hierarchical FrameworkR01GM100469 · NIGMS · NEW YORK UNIVERSITY · PI SCHLICK, TAMAR · 2011 to 2014
$1.5M
Computational studies of in vitro selection of RNAsR01GM081410 · NIGMS · NEW YORK UNIVERSITY · PI SCHLICK, TAMAR · 2009 to 2012
$1.2M
Mechanisms of DNA PolymerasesR01ES012692 · NIEHS · NEW YORK UNIVERSITY · PI SCHLICK, TAMAR · 2005 to 2007
$843k
NIEHS NIH HHS ES01269201NIEHS NIH HHS R01 ES012692NIGMS NIH HHS GM081410NIGMS NIH HHS R01 GM081410NIGMS NIH HHS R01 GM100469
6 · The paper itself

Abstract

RNA molecules are important cellular components involved in many fundamental biological processes. Understanding the mechanisms behind their functions requires RNA tertiary structure knowledge. Although modeling approaches for the study of RNA structures and dynamics lag behind efforts in protein folding, much progress has been achieved in the past two years. Here, we review recent advances in RNA folding algorithms, RNA tertiary motif discovery, applications of graph theory approaches to RNA structure and function, and in silico generation of RNA sequence pools for aptamer design. Advances within each area can be combined to impact many problems in RNA structure and function.

Indexed as

Computational BiologyNucleic Acid ConformationAnimalsDatabases, GeneticHumansMolecular Dynamics SimulationRNASoftwareRNA

Identifiers

PMID21514143
PMCPMC3112238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.