ArticleMolecular immunology2011
Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1).
Article in Molecular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- The Tim gene family in efferocytosis.Genes & genomics · 2020Review
- Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.Journal of cellular physiology · 2018Article
- Acute stimulation generates Tim-3-expressing T helper type 1 CD4 T cells that persist in vivo and show enhanced effector function.Immunology · 2018Article
- Determinants in the Ig Variable Domain of Human HAVCR1 (TIM-1) Are Required To Enhance Hepatitis C Virus Entry.Journal of virology · 2018Article
- G protein αAmerican journal of physiology. Renal physiology · 2016Article
- Mast cell activation is enhanced by Tim1:Tim4 interaction but not by Tim-1 antibodies.F1000Research · 2016Article
- Apoptotic cell recognition receptors and scavenger receptors.Immunological reviews · 2016Review
- Immune Regulation and Antitumor Effect of TIM-1.Journal of immunology research · 2016Review
- Regulation of T cell responses by the receptor molecule Tim-3.Immunologic research · 2014Review
- Characterizing functional domains for TIM-mediated enveloped virus entry.Journal of virology · 2014Article
- Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Tim-1 regulates Th2 responses in an airway hypersensitivity model.European journal of immunology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The gene encoding T cell immunoglobulin and mucin domain-1 (Tim-1) is linked to atopy and asthma susceptibility in mice and humans. Tim-1 is a transmembrane protein expressed on activated lymphocytes and appears to have a role as a co-stimulatory receptor in T cells. The protein has not been shown to have enzymatic activity but contains a site within its cytoplasmic tail predicted to be a target for tyrosine kinases. Here, we show that Tim-1 can associate with the kinase Fyn, a member of the Src family of tyrosine kinases. This association does not require Fyn's kinase activity and is independent of the phosphorylation of a conserved tyrosine present within the cytoplasmic tail of Tim-1. Fyn is necessary for phosphorylation of this tyrosine in Tim-1 and the phosphorylation of Tim-1 varies with the levels of Fyn present in cells. These data suggest a role for Fyn in the signaling downstream of Tim-1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.