ArticleNeuroImage2011
Pulsed infrared light alters neural activity in rat somatosensory cortex in vivo.
Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed.
- Thermophoresis induced by photothermal shock alters reversal potential and capacitance in neurons.Biophysical journal · 2026Article
- Cortical neuron calcium response to infrared neural stimulation depends on the spatiotemporal thermal gradient.Biomedical optics express · 2026Article
- Mid-Infrared Light Exhibits Tissue-Specific Transmittance and Modulates Neural Signal Conduction Along Axons.Neuroscience bulletin · 2026Article
- Local infrared stimulation modulates spontaneous cortical slow wave dynamics in anesthetized rats.Scientific reports · 2026Article
- Electrophysiological Response of the Non-Anesthetized Primate Brain to Minimally Invasive Local Infrared Neural Stimulation in Chronic Experiments.Brain topography · 2025Article
- Focal thalamic infrared neural stimulation propagates dynamical transformations in auditory cortex.Journal of neural engineering · 2025Article
- High density laminar recordings reveal cell type and layer specific responses to infrared neural stimulation in the rat neocortex.Scientific reports · 2024Article
- Infrared neuroglial modulation of spinal locomotor networks.Scientific reports · 2024Article
- A novel interface for cortical columnar neuromodulation with multipoint infrared neural stimulation.Nature communications · 2024Article
- Quantifying tissue temperature changes induced by infrared neural stimulation: numerical simulation and MR thermometry.Biomedical optics express · 2024Article
- Practical Bayesian Inference in Neuroscience: Or How I Learned to Stop Worrying and Embrace the Distribution.eNeuro · 2024Article
- Article
- Two-photon imaging of excitatory and inhibitory neural response to infrared neural stimulation.Neurophotonics · 2024Article
- Practical Bayesian Inference in Neuroscience: Or How I Learned To Stop Worrying and Embrace the Distribution.bioRxiv : the preprint server for biology · 2024Article
- Characterization and closed-loop control of infrared thalamocortical stimulation produces spatially constrained single-unit responses.PNAS nexus · 2024Article
- Advances in the Regulation of Neural Function by Infrared Light.International journal of molecular sciences · 2024Review
- Somatosensory integration in robot-assisted motor restoration post-stroke.Frontiers in aging neuroscience · 2024Article
- Spatially specific, closed-loop infrared thalamocortical deep brain stimulation.bioRxiv : the preprint server for biology · 2023Article
- Thermal neuromodulation using pulsed and continuous infrared illumination in a penicillin-induced acute epilepsy model.Scientific reports · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Pulsed infrared light has shown promise as an alternative to electrical stimulation in applications where contact free or high spatial precision stimulation is desired. Infrared neural stimulation (INS) is well characterized in the peripheral nervous system; however, to date, research has been limited in the central nervous system. In this study, pulsed infrared light (λ=1.875 μm, pulse width=250 μs, radiant exposure=0.01-0.55 J/cm(2), fiber size=400 μm, repetition rate=50-200 Hz) was used to stimulate the somatosensory cortex of anesthetized rats, and its efficacy was assessed using intrinsic optical imaging and electrophysiology techniques. INS was found to evoke an intrinsic response of similar magnitude to that evoked by tactile stimulation (0.3-0.4% change in intrinsic signal magnitude). A maximum deflection in the intrinsic signal was measured to range from 0.05% to 0.4% in response to INS, and the activated region of cortex measured approximately 2mm in diameter. The intrinsic signal magnitude increased with faster laser repetition rates and increasing radiant exposures. Single unit recordings indicated a statistically significant decrease in neuronal firing that was observed at the onset of INS stimulation (0.5s stimulus) and continued up to 1s after stimulation onset. The pattern of neuronal firing differed from that observed during tactile stimulation, potentially due to a different spatial integration field of the pulsed infrared light compared to tactile stimulation. The results demonstrate that INS can be used safely and effectively to manipulate neuronal firing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.