ArticleJournal of controlled release : official journal of the Controlled Release Society2011
Structure-property relationship in cytotoxicity and cell uptake of poly(2-oxazoline) amphiphiles.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- The NFIL3-MYC signaling axis: a novel therapeutic target and prognostic marker in high-risk multiple myeloma.Biomarker research · 2026Article
- PET-Trackable Carborane-Conjugated Star-Shaped Poly(2-Oxazoline) Scaffold with High Boron Payload and Improved Aqueous Solubility for Potential Application in Boron Neutron Capture Therapy.Biomacromolecules · 2026Article
- Polyoxazolines with Cholesterol Lipid Anchor for Fast Intracellular Delivery.Macromolecular bioscience · 2024Article
- Poly(2-oxazoline)-Based Thermoresponsive Stomatocytes.Biomacromolecules · 2024Article
- Nanoparticle-Based Drug Delivery Systems in Inhaled Therapy: Improving Respiratory Medicine.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Effect of Solvent Properties on the Critical Solution Temperature of Thermoresponsive Polymers.International journal of molecular sciences · 2024Article
- A Novel PEtOx-Based Nanogel Targeting Prostate Cancer Cells for Drug Delivery.Macromolecular bioscience · 2024Article
- Poly(2-oxazoline)/saRNA Polyplexes for Targeted and Nonviral Gene Delivery.Biomacromolecules · 2023Article
- Biological ActivityBiomacromolecules · 2023Article
- Pharmacokinetics of Intramuscularly Administered Thermoresponsive Polymers.Advanced healthcare materials · 2022Article
- The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging.European journal of drug metabolism and pharmacokinetics · 2021Review
- Optimizing an Antioxidant TEMPO Copolymer for Reactive Oxygen Species Scavenging and Anti-Inflammatory EffectsBioconjugate chemistry · 2021Article
- Effect of Dexamethasone on Thermoresponsive Behavior of Poly(2-Oxazoline) Diblock Copolymers.Polymers · 2021Article
- Equilibrium Swelling of Biocompatible Thermo-Responsive Copolymer Gels.Gels (Basel, Switzerland) · 2021Article
- Poly(2-oxazoline)- and Poly(2-oxazine)-Based Self-Assemblies, Polyplexes, and Drug Nanoformulations-An Update.Advanced healthcare materials · 2021Review
- Alternative to Poly(2-isopropyl-2-oxazoline) with a Reduced Ability to Crystallize and Physiological LCST.International journal of molecular sciences · 2021Article
- Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters.Pharmaceutics · 2021Review
- Serum Protects Cells and Increases Intracellular Delivery of Molecules by Nanoparticle-Mediated Photoporation.International journal of nanomedicine · 2021Article
- Low dose novel PARP-PI3K inhibition via nanoformulation improves colorectal cancer immunoradiotherapy.Materials today. Bio · 2020Article
- Selective Partial Hydrolysis of 2-isopropyl-2-oxazoline Copolymers towards Decreasing the Ability to Crystallize.Materials (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The family of poly(2-oxazoline)s (POx) is being increasingly investigated in the context of biomedical applications. We tested the relative cytotoxicity of POx and were able to confirm that these polymers are typically not cytotoxic even at high concentrations. Furthermore, we report structure-uptake relationships of a series of amphiphilic POx block copolymers that have different architectures, molar mass and chain termini. The rate of endocytosis can be fine-tuned over a broad range by changing the polymer structure. The cellular uptake increases with the hydrophobic character of the polymers and is observed even at nanomolar concentrations. Considering the structural versatility of this class of polymers, the relative ease of preparation and their stability underlines the potential of POx as a promising platform candidate for the preparation of next-generation polymer therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.