Evidence map›Paper›PMID 21513695›Full record

ReviewArchives of biochemistry and biophysics2011

Regulation of ciliary motility: conserved protein kinases and phosphatases are targeted and anchored in the ciliary axoneme.

Maureen Wirschell, Ryosuke Yamamoto, Lea Alford, Avanti Gokhale, Anne Gaillard, Winfield S Sale

Open access · greenAbstract readReview
In one paragraph

Review in Archives of biochemistry and biophysics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 62 citations in OpenAlex.

  1. Mouse radial spoke 3 is a metabolic and regulatory hub in cilia.Nature structural & molecular biology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Illumination of understudied ciliary kinases.Frontiers in molecular biosciences · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Cryo-EM structure of an active central apparatus.Nature structural & molecular biology · 2022
    Article
  10. Article
  11. Article
  12. Structural organization of the intermediate and light chain complex of Chlamydomonas ciliary I1 dynein.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  13. Motile cilia genetics and cell biology: big results from little mice.Cellular and molecular life sciences : CMLS · 2021
    Review
  14. Review
  15. Scaffold subunits support associated subunit assembly in theProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  16. Review
  17. Review
  18. Survey of the Ciliary Motility Machinery ofFrontiers in genetics · 2019
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maureen WirschellEmory University School of Medicine, Department of Cell Biology, Atlanta, GA 30322, USA. mwirschell@gmail.com
Ryosuke Yamamoto
Lea Alford
Avanti Gokhale
Anne Gaillard
Winfield S Sale
Emory University · USSam Houston State University · US

Funding

Functional Substructure of Flagellar DyneinR37GM051173 · NIGMS · EMORY UNIVERSITY · PI SALE, WINFIELD S · 2002 to 2011
$4.0M
FUNCTIONAL SUBSTRUCTURE OF FLAGELLAR DYNEINR01GM051173 · NIGMS · EMORY UNIVERSITY · PI SALE, WINFIELD S · 1994 to 2020
$3.6M
NIGMS NIH HHS R01 GM051173NIGMS NIH HHS R37 GM051173
6 · The paper itself

Abstract

Recent evidence has revealed that the dynein motors and highly conserved signaling proteins are localized within the ciliary 9+2 axoneme. One key mechanism for regulation of motility is phosphorylation. Here, we review diverse evidence, from multiple experimental organisms, that ciliary motility is regulated by phosphorylation/dephosphorylation of the dynein arms through kinases and phosphatases that are anchored immediately adjacent to their axonemal substrates.

Indexed as

Conserved SequenceMovementAnimalsAxonemeCiliaHumansPhosphoric Monoester HydrolasesProtein KinasesPhosphoric Monoester HydrolasesProtein Kinases

Identifiers

PMID21513695
PMCPMC3114296
OpenAlexW2012968589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.