ArticleRespiratory research2011
Pulmonary arterial dysfunction in insulin resistant obese Zucker rats.
Article in Respiratory research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Is Inducible Nitric Oxide Synthase (iNOS) Promising as a New Target Against Pulmonary Hypertension?Antioxidants (Basel, Switzerland) · 2025Review
- Effect of Carotid Body Denervation on Systemic Endothelial Function in a Diabetic Animal Model.Advances in experimental medicine and biology · 2023Article
- Prognostic significance of insulin resistance in pulmonary hypertension.ESC heart failure · 2022Article
- Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives.Current obesity reports · 2021Review
- When Two Pandemics Meet: Why Is Obesity Associated with Increased COVID-19 Mortality?Med (New York, N.Y.) · 2020Review
- Pulmonary vascular dysfunction in metabolic syndrome.The Journal of physiology · 2019Review
- Article
- Comparison of Pulmonary and Systemic NO- and PGIOxidative medicine and cellular longevity · 2018Article
- Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury.Experimental and therapeutic medicine · 2016Article
- Sympathetic hyper-excitation in obesity and pulmonary hypertension: physiological relevance to the 'obesity paradox'.International journal of obesity (2005) · 2016Article
- Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia.Pulmonary circulation · 2014Article
- Insulin resistance in pulmonary arterial hypertension, is it a novel disease modifier?Research in cardiovascular medicine · 2014Article
- Hypoxia-inducible factor 1 alpha contributes to pulmonary vascular dysfunction in lung ischemia-reperfusion injury.International journal of clinical and experimental pathology · 2014Article
- Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- A potential role for insulin resistance in experimental pulmonary hypertension.The European respiratory journal · 2013Article
- Obesity and pulmonary hypertension: a review of pathophysiologic mechanisms.Journal of obesity · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin resistance and obesity are strongly associated with systemic cardiovascular diseases. Recent reports have also suggested a link between insulin resistance with pulmonary arterial hypertension. The aim of this study was to analyze pulmonary vascular function in the insulin resistant obese Zucker rat.
methodsLarge and small pulmonary arteries from obese Zucker rat and their lean counterparts were mounted for isometric tension recording. mRNA and protein expression was measured by RT-PCR or Western blot, respectively. KV currents were recorded in isolated pulmonary artery smooth muscle cells using the patch clamp technique.
resultsRight ventricular wall thickness was similar in obese and lean Zucker rats. Lung BMPR2, KV1.5 and 5-HT2A receptor mRNA and protein expression and KV current density were also similar in the two rat strains. In conductance and resistance pulmonary arteries, the similar relaxant responses to acetylcholine and nitroprusside and unchanged lung eNOS expression revealed a preserved endothelial function. However, in resistance (but not in conductance) pulmonary arteries from obese rats a reduced response to several vasoconstrictor agents (hypoxia, phenylephrine and 5-HT) was observed. The hyporesponsiveness to vasoconstrictors was reversed by L-NAME and prevented by the iNOS inhibitor 1400W.
conclusionsIn contrast to rat models of type 1 diabetes or other mice models of insulin resistance, the obese Zucker rats did not show any of the characteristic features of pulmonary hypertension but rather a reduced vasoconstrictor response which could be prevented by inhibition of iNOS.
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