ArticleChinese medicine2011
Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia.
Article in Chinese medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04249869 (The Effect of Traditional Chinese Medicine), which is not on this map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Traditional Chinese Medicine (VGH-AD1) on Patients With Alzheimer's Disease: A Double-blinded Randomized Placebo-controlled Cross-over Study
Who cites it
26 citing papers in PubMed.
- Trial
- Article
- Methanol extract ofFrontiers in pharmacology · 2024Article
- Traditional East Asian Herbal Medicine Treatment for Alzheimer's Disease: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Preventing Dementia Using Saffron, The Kampo Medicine, Kamiuntanto, and Their Combination, Kamiuntantokabankoka.Frontiers in pharmacology · 2021Review
- Overview of Cannabis including Kampo Medicine and Therapy for Treatment of Dementia: A Review.Frontiers in pharmacology · 2021Review
- Oxyphylla A Promotes Degradation of α-Synuclein for NeuroprotectionAging and disease · 2020Article
- Article
- Inhibitory effect of carvacrol on lipopolysaccharide-induced memory impairment in rats.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020Article
- Traditional Oriental Medicines and Alzheimer's Disease.Aging and disease · 2019Review
- Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease.Aging and disease · 2019Article
- Modified Huang-Lian-Jie-Du Decoction Ameliorates AOxidative medicine and cellular longevity · 2019Article
- Gypenosides Attenuate Lipopolysaccharide-Induced Neuroinflammation and Memory Impairment in Rats.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Article
- Bioprospecting of South African Plants as a Unique Resource for Bioactive Endophytic Microbes.Frontiers in pharmacology · 2018Review
- Application of Ferulic Acid for Alzheimer's Disease: Combination of Text Mining and Experimental Validation.Frontiers in neuroinformatics · 2018Article
- Protective Effects ofOxidative medicine and cellular longevity · 2018Article
- Neurogenic Traditional Chinese Medicine as a Promising Strategy for the Treatment of Alzheimer's Disease.International journal of molecular sciences · 2017Review
- Vascular Contributions to Cognitive Impairment and Treatments with Traditional Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2016Review
- Lycium barbarum polysaccharides protected human retinal pigment epithelial cells against oxidative stress-induced apoptosis.International journal of ophthalmology · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease and vascular dementia are two major diseases associated with dementia, which is common among the elderly. While the etiology of dementia is multi-factorial and complex, neurodegeneration may be the major cause of these two diseases. Effective drugs for treating dementia are still to be discovered. Current western pharmacological approaches against neurodegeneration in dementia develop symptom-relieving and disease-modifying drugs. Current integrative and holistic approaches of Chinese medicine to discovering drugs for neurodegeneration in dementia include (1) single molecules from the herbs, (2) standardized extracts from a single herb, and (3) herbal formula with definite composition. This article not only reviews the concept of dementia in western medicine and Chinese medicine but also evaluates the advantages and disadvantages of these approaches.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.