Novel approaches to assessing cardiac safety--proceedings of a workshop: regulators, industry and academia discuss the future of in silico cardiac modelling to predict the proarrhythmic safety of drugs.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

8 citing papers in PubMed.

1. Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk.Cell reports. Medicine · 2020
   Article
2. Transmural and rate-dependent profiling of drug-induced arrhythmogenic risks through in silico simulations of multichannel pharmacology.Scientific reports · 2019
   Article
3. Cardiovascular drug discovery: a perspective from a research-based pharmaceutical company.Cold Spring Harbor perspectives in medicine · 2014
   Review
4. Combining wet and dry research: experience with model development for cardiac mechano-electric structure-function studies.Cardiovascular research · 2013
   Review
5. Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentials.British journal of pharmacology · 2013
   Article
6. Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.British journal of pharmacology · 2012
   Review
7. Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.Journal of pharmacological and toxicological methods
   Article
8. Prediction of Thorough QT study results using action potential simulations based on ion channel screens.Journal of pharmacological and toxicological methods
   Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

8 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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