Trial reportLipids2011
Fish oil supplementation during lactation: effects on cognition and behavior at 7 years of age.
Trial report in Lipids, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 1 citations in OpenAlex.
- Omega-3 fatty acid addition during pregnancy.The Cochrane database of systematic reviews · 2018Pooled it
- Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy.The Cochrane database of systematic reviews · 2016Pooled it
- Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood.The Cochrane database of systematic reviews · 2015Pooled it
- Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development.The Cochrane database of systematic reviews · 2015Pooled it
- Trial
- Trial
- Trial
- Reduced anxiety in forensic inpatients after a long-term intervention with Atlantic salmon.Nutrients · 2014Trial
- Review
- Executive functions and the ω-6-to-ω-3 fatty acid ratio: a cross-sectional study.The American journal of clinical nutrition · 2017Article
- Docosahexaenoic Acid and Arachidonic Acid Nutrition in Early Development.Advances in pediatrics · 2016Review
- DHA Effects in Brain Development and Function.Nutrients · 2016Review
- Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study.Nutrients · 2015Observational
- Docosahexaenoic acid status at 9 months is inversely associated with communicative skills in 3-year-old girls.Maternal & child nutrition · 2013Article
- Infant feeding and childhood cognition at ages 3 and 7 years: Effects of breastfeeding duration and exclusivity.JAMA pediatrics · 2013Article
- Nutrition and the psychoneuroimmunology of postpartum depression.Nutrition research reviews · 2012Review
- A Systematic Review of Omega-3 Fatty Acid Consumption and Cognitive Outcomes in Neurodevelopment.American journal of lifestyle medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early accumulation of n-3 long-chain PUFA (LCPUFA) in the brain may contribute to differences in later cognitive abilities. In this study, our objective was to examine whether fish oil (FO) supplementation during lactation affects processing speed, working memory, inhibitory control, and socioemotional development at 7 years. Danish mothers (n = 122) were randomized to FO [1.5 g/d n-3 LCPUFA] or olive oil (OO) supplementation during the first 4 months of lactation. The trial also included a high-fish intake (HFI) reference group (n = 53). Ninety-eight children were followed-up with an assessment of processing speed, an age-appropriate Stroop task, and the Strength and Difficulties Questionnaire at 7 year. A group effect of the intervention (FO vs. OO) was found in prosocial behavior scores; this negative effect was carried by the boys. Exploratory analyses including all participants revealed the speed of processing scores were predicted by maternal n-3 LCPUFA intake during the intervention period (negative relation) and maternal education (positive relation). Stroop scores indicative of working memory and inhibitory control were predicted by infant erythrocyte DHA status at 4 months of age (negative relation). Early fish oil supplementation may have a negative effect on later cognitive abilities. Speed of processing and inhibitory control/working memory are differentially affected, with speed of processing showing effects of fish oil intake as a whole, whereas inhibitory control/working memory was related more specifically to DHA status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.