ReviewTransfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie2008
Effects of storage of red cells.
Review in Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of packed red blood cell storage duration on post-transfusion clinical outcomes: a meta-analysis and systematic review.Intensive care medicine · 2015Pooled it
- Transfusion of older stored blood and risk of death: a meta-analysis.Transfusion · 2012Pooled it
- Microcirculatory effects of the transfusion of leukodepleted or non-leukodepleted red blood cells in patients with sepsis: a pilot study.Critical care (London, England) · 2014Trial
- Impact of pre-bypass ultrafiltration on prime values and clinical outcomes in neonatal and infant cardiopulmonary bypass.The journal of extra-corporeal technology · 2023Article
- In vitro exposure of whole blood to a cannabinoid mixture impairs the quality of red blood cells and platelets.Blood transfusion = Trasfusione del sangue · 2023Article
- Comparison of Two Alternative Procedures to Obtain Packed Red Blood Cells for β-Thalassemia Major Transfusion Therapy.Biomolecules · 2021Article
- Landmark Papers on Blood and Component Transfusion Therapy in the Critically Ill: A Critical Analysis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2019Article
- Biochemical storage lesions occurring in nonirradiated and irradiated red blood cells: a brief review.BioMed research international · 2015Review
- Non-leukodepleted red blood cell transfusion in sepsis patients: beyond oxygenation, is there a risk of inflammation?Critical care (London, England) · 2014Article
- Influence of storage time and amount of red blood cell transfusion on postoperative renal function: an observational cohort study.Heart, lung and vessels · 2013Article
- The effectiveness of postoperative neutrophils to lymphocytes ratio in predicting long-term recurrence after stomach cancer surgery.Journal of the Korean Surgical Society · 2012Article
- Biomarker analysis of stored blood products: emphasis on pre-analytical issues.International journal of molecular sciences · 2010Review
- [Risks and side effects of blood transfusion].Der Orthopade · 2009Review
- Transfusion Reactions.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2008Article
- In vitro lysis and acute transfusion reactions with hemolysis caused by inappropriate storage of canine red blood cell products.Journal of veterinary internal medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryDuring storage, red blood cells intended for transfusion undergo progressive changes affecting survival and function. Some of these in vitro changes are partly restored in vivo after transfusion, and their clinical effects are largely unknown. We evaluated publications of clinical studies comparing storage times in connection with red blood cell transfusion using physiological or clinical outcomes. A few prospective randomised studies in humans investigated physiological outcomes or oxygen kinetics. Sixteen observational studies comparing clinical outcome yielded contradictory results regarding the effect of red cell storage on mortality, length of intensive care and hospital stay, infections, organ failure, and composite adverse effects. The use of different red blood cell products further obscures the issue. Available studies provide no evidence that longer stored red cells are more harmful than younger red cells. However, such an effect may occur under extreme clinical conditions of severe anaemia or septicaemia, but this can only be answered by randomised studies controlling for confounding factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.