ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2011
Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- K2P channels as emerging therapeutic targets for pain: insights from functional studies and transcriptomic analyses.Frontiers in pharmacology · 2026Review
- Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age.American journal of physiology. Renal physiology · 2024Article
- Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Piezo1 in Digestive System Function and Dysfunction.International journal of molecular sciences · 2023Review
- Efficacy of Supplemental Diet Gels for Preventing Postoperative Weight Loss in Mice (Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022Review
- Pain in chronic prostatitis and the role of ion channels: a brief overview.British journal of pain · 2022Article
- Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation.Frontiers in immunology · 2022Review
- Targeting Two-Pore-Domain Potassium Channels by Mechanical Stretch Instantaneously Modulates Action Potential Transmission in Mouse Sciatic Nerves.ACS chemical neuroscience · 2021Article
- MiR-200c-3p affects cochlear hair cells damaged by oxidative stress via modulating Taok1 expression.American journal of translational research · 2021Article
- The Macro- and Micro-Mechanics of the Colon and Rectum II: Theoretical and Computational Methods.Bioengineering (Basel, Switzerland) · 2020Review
- Visceral pain from colon and rectum: the mechanotransduction and biomechanics.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Tandem pore TWIK-related potassium channels and neuroprotection.Neural regeneration research · 2019Review
- Characterization of temperature-sensitive leak KMolecular brain · 2018Article
- Voltage-gated sodium channels: (NaThe Journal of physiology · 2018Review
- Dynamic regulation of TREK1 gating by Polycystin 2 via a Filamin A-mediated cytoskeletal Mechanism.Scientific reports · 2017Article
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- Enhanced Expression of TREK-1 Is Related with Chronic Constriction Injury of Neuropathic Pain Mouse Model in Dorsal Root Ganglion.Biomolecules & therapeutics · 2016Article
- Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function.Cellular & molecular immunology · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
TREK-1, TREK-2 and TRAAK are mechanosensitive two-pore domain K(+) (K(2P)) channels thought to be involved in the attenuation of mechanotransduction. Because colon inflammation is associated with colon mechanohypersensitivity, we hypothesized that the role of these channels in colon sensory (dorsal root ganglion, DRG) neurons would be reduced by colon inflammation. Accordingly, we studied the functional expression of mechanosensitive K(2P) channels in colon sensory neurons in both thoracolumbar (TL) and lumbosacral (LS) DRG that represent the splanchnic and pelvic nerve innervations of the colon, respectively. In colon DRG neurons identified by retrograde tracer previously injected into the colon wall, 62% of TL neurons and 83% of LS neurons expressed at least one of three K(2P) channel mRNAs; the proportion of neurons expressing the TREK-1 gene was greater in LS than in TL DRG. In electrophysiological studies, single-channel activities of TREK-1a, TREK-1b, TREK-2, and TRAAK-like channels were detected in cultured colon DRG neuronal membranes. After trinitrobenzene sulfonic acid-induced colon inflammation, we observed significant decreases in the amount of TREK-1 mRNA, in the response of TREK-2-like channels to membrane stretch, and in the whole cell outward current during osmotic stretch in LS colon DRG neurons. These findings document that the majority of DRG neurons innervating the mouse colon express mechanosensitive K(2P) channels and suggest that a decrease in their expression and activities contributes to the increased colon mechanosensitivity that develops in inflammatory bowel conditions.
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