ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Skeletal muscle metabolism in individuals with spinal cord injury.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Pooled it
- Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Pooled it
- The Effect of Lower Limb Combined Neuromuscular Electrical Stimulation on Skeletal Muscle Signaling for Glucose Utilization, Myofiber Distribution, and Metabolic Function after Spinal Cord Injury.International journal of environmental research and public health · 2023Trial
- Exercise and Autonomic Cardiovascular Function-Insights From Spinal Cord-Injured Humans: A Narrative Review.Acta physiologica (Oxford, England) · 2026Review
- The impact of muscle oxidative capacity on neuromuscular recovery after exercise-induced muscle damage.European journal of applied physiology · 2026Article
- Altered acute metabolic response to muscle stimulation in muscular dystrophic mice observed by phosphorus-31 magnetic resonance spectroscopy and fingerprinting.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Methodological considerations on near-infrared spectroscopy derived muscle oxidative capacity.European journal of applied physiology · 2024Article
- Lesion level-dependent systemic muscle wasting after spinal cord injury is mediated by glucocorticoid signaling in mice.Science translational medicine · 2023Article
- Relationship between muscle venous blood oxygenation and near-infrared spectroscopy: quantitative analysis of the Hb and Mb contributions.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- The Physiology of Neurogenic Obesity: Lessons from Spinal Cord Injury Research.Obesity facts · 2023Review
- SS-31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice.Physiological reports · 2022Article
- Article
- Blood volume versus deoxygenated NIRS signal: computational analysis of the effects muscle OJournal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Substrate metabolism during recovery from circuit resistance exercise in persons with spinal cord injury.European journal of applied physiology · 2021Article
- Time-to-treatment window and cross-sex potential of βToxicology and applied pharmacology · 2021Article
- Methodological considerations for near-infrared spectroscopy to assess mitochondrial capacity after spinal cord injury.The journal of spinal cord medicine · 2020Observational
- Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles.Aging cell · 2020Article
- βExperimental neurology · 2019Article
- Key Glycolytic Metabolites in Paralyzed Skeletal Muscle Are Altered Seven Days after Spinal Cord Injury in Mice.Journal of neurotrauma · 2019Article
- Femoral venous flow velocity during passive ankle exercise in patients with chronic spinal cord injury.Journal of physical therapy science · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
With increasing survival rates in people with spinal cord injuries (SCI), detection and prevention of metabolic and cardiovascular disease have become increasingly important. Few studies have evaluated in vivo mitochondrial function in paralyzed skeletal muscle. The purpose of this study was to compare oxidative muscle metabolism using the rate of phosphocreatine (PCr) resynthesis measured by magnetic resonance spectroscopy (MRS) in people with SCI and able-bodied (AB) controls. Eight subjects with complete SCI (American Spinal Injury Association Impairment Scale A, levels T3-T12, injury duration 2-13 years) were compared with 12 AB controls. T1-weighted (1)H MR images of the thigh were taken to identify skeletal muscle. Phosphorous MRS was performed with a 13 × 13-cm(2) surface coil placed on the right vastus lateralis in a 3 Tesla clinical MRI scanner. PCr resynthesis was measured after electrical stimulation for 60 s at 4 Hz in SCI and AB and in AB subjects after 39 s of voluntary isometric contractions. Resting metabolites were not different between SCI and AB, except for an elevated phosphodiester peak. PCr recovery was slower in AB subjects using electrical stimulation compared with voluntary exercise (28.4 ± 6.1 vs. 41.5 ± 4.3 s; P < 0.05). PCr recovery rates and calculated muscle maximum oxidative capacity in SCI were both 52% of electrically stimulated AB (P < 0.001). In vivo oxidative metabolism was reduced in paralyzed muscle to a similar extent as seen in people with mitochondrial myopathies and heart failure.
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Registered trials
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