ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Relationship between upper and lower limb conduit artery vasodilator function in humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Impacts of Physical Inactivity Models on Endothelial Function: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Effects of Alternating Mild-Cold and Hot Water Immersion on Lower-Leg Blood Flow Following Immersion in Healthy Young Adults.Scandinavian journal of medicine & science in sports · 2026Trial
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- The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: a Pilot Study.Reproductive sciences (Thousand Oaks, Calif.) · 2021Trial
- The acute effects of interrupting prolonged sitting with stair climbing on vascular and metabolic function after a high-fat meal.European journal of applied physiology · 2020Trial
- The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial.Experimental gerontology · 2013Trial
- Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans.Experimental physiology · 2012Trial
- Microvascular dysfunction in chronic kidney disease: A feasibility study.Clinical physiology and functional imaging · 2026Article
- The impact of a 12-week high-intensity interval training program on popliteal vascular responses to prolonged sitting.European journal of applied physiology · 2026Article
- Take charge during treatment: a protocol for a pilot study to evaluate the impact of exercise on cardiovascular biomarkers among black and white breast cancer patients undergoing treatment.Cardio-oncology (London, England) · 2025Article
- Leg vascular function with advancing age in men: the impact of physical activity and endurance exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Cross-sectional associations between physical activity and sedentary time with cardiovascular health in children from the ALSPAC study using compositional data analysis.Scientific reports · 2025Article
- Endothelial and exercise vasodilation are reduced in postmenopausal females with obesity versus lean and overweight.International journal of obesity (2005) · 2024Article
- Vascular dysfunction in females post-menopause with obesity: an ultrasonic view.International journal of obesity (2005) · 2024Article
- The effect of self-identified arm dominance on exercising forearm hemodynamics and skeletal muscle desaturation.PloS one · 2024Article
- Biological sex does not influence the peak cardiac output response to twelve weeks of sprint interval training.Scientific reports · 2023Article
- Mechanistic, participant, and movement-related factors that contribute to low-flow-mediated constriction.European journal of applied physiology · 2023Review
- Assessment of aortic to peripheral vascular stiffness and gradient by segmented upper limb PWV in healthy and hypertensive individuals.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
Abstract
Brachial artery flow-mediated dilation (FMD) is a strong predictor of future cardiovascular disease and is believed to represent a "barometer" of systemic endothelial health. Although a recent study [Padilla et al. Exp Biol Med (Maywood) 235: 1287-1291, 2010] in pigs confirmed a strong correlation between brachial and femoral artery endothelial function, it is unclear to what extent brachial artery FMD represents a systemic index of endothelial function in humans. We conducted a retrospective analysis of data from our laboratory to evaluate relationships between the upper (i.e., brachial artery) vs. lower limb (superficial femoral n = 75; popliteal artery n = 32) endothelium-dependent FMD and endothelium-independent glyceryl trinitrate (GTN)-mediated dilation in young, healthy individuals. We also examined the relationship between FMD assessed in both brachial arteries (n = 42). There was no correlation between brachial and superficial femoral artery FMD (r(2) = 0.008; P = 0.46) or between brachial and popliteal artery FMD (r(2) = 0.003; P = 0.78). However, a correlation was observed in FMD between both brachial arteries (r(2) = 0.34; P < 0.001). Brachial and superficial femoral artery GTN were modestly correlated (r(2) = 0.13; P = 0.007), but brachial and popliteal artery GTN responses were not (r(2) = 0.08; P = 0.11). Collectively, these data indicate that conduit artery vasodilator function in the upper limbs (of healthy humans) is not predictive of that in the lower limbs, whereas measurement of FMD in one arm appears to be predictive of FMD in the other. These data do not support the hypothesis that brachial artery FMD in healthy humans represents a systemic index of endothelial function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.