Evidence map›Paper›PMID 21511999›Full record

ArticleScience (New York, N.Y.)2011

Comparative functional genomics of the fission yeasts.

Nicholas Rhind, Zehua Chen, Moran Yassour, Dawn A Thompson, Brian J Haas, Naomi Habib, Ilan Wapinski, Sushmita Roy, Michael F Lin, David I Heiman and 50 more

Abstract readComparative Study
In one paragraph

Article in Science (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 317 papers.

0numbers the graph read from it
0cells of the map it votes in
317citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

317 citing papers in PubMed.

  1. Article
  2. Article
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  8. Article
  9. Pan-genome assembly of vine tea (Horticulture research · 2026
    Article
  10. Article
  11. Article
  12. TheCells · 2025
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Regulation of Yeast Cytokinesis by Calcium.Journal of fungi (Basel, Switzerland) · 2025
    Review
  20. Diploidy confers genomic instability inbioRxiv : the preprint server for biology · 2025
    Article

257 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

60 authors.

Nicholas RhindBiochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. nick.rhind@umassmed.edu
Zehua Chen
Moran Yassour
Dawn A Thompson
Brian J Haas
Naomi Habib
Ilan Wapinski
Sushmita Roy
Michael F Lin
David I Heiman
Sarah K Young
Kanji Furuya
Yabin Guo
Alison Pidoux
Huei Mei Chen
Barbara Robbertse
Jonathan M Goldberg
Keita Aoki
Elizabeth H Bayne
Aaron M Berlin
Christopher A Desjardins
Edward Dobbs
Livio Dukaj
Lin Fan
Michael G FitzGerald
Courtney French
Sharvari Gujja
Klavs Hansen
Dan Keifenheim
Joshua Z Levin
Rebecca A Mosher
Carolin A Müller
Jenna Pfiffner
Margaret Priest
Carsten Russ
Agata Smialowska
Peter Swoboda
Sean M Sykes
Matthew Vaughn
Sonya Vengrova
Ryan Yoder
Qiandong Zeng
Robin Allshire
David Baulcombe
Bruce W Birren
William Brown
Karl Ekwall
Manolis Kellis
Janet Leatherwood
Henry Levin
Hanah Margalit
Rob Martienssen
Conrad A Nieduszynski
Joseph W Spatafora
Nir Friedman
Jacob Z Dalgaard
Peter Baumann
Hironori Niki
Aviv Regev
Chad Nusbaum

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Regulation And Function Of RetroelementsZIAHD001009 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LEVIN, HENRY L. · 2009 to 2025
$21.8M
RNAi, Histone Modification and the DDB1/CPSF-Like Complex Rik1R01GM076396 · NIGMS · COLD SPRING HARBOR LABORATORY · PI MARTIENSSEN, ROBERT A · 2007 to 2020
$4.9M
Regulatory Morif Discovery in the Human Genome Using Comparative GenomicsR01HG004037 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KELLIS, MANOLIS · 2007 to 2015
$3.9M
The temporal reconfiguration of regulatory networks: From yeast to cancerDP1OD003958 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI REGEV, AVIV · 2008 to 2011
$3.3M
The Role of MRN in the S-Phase DNA Damage CheckpointR01GM069957 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RHIND, NICHOLAS R · 2004 to 2013
$2.8M
Biotechnology and Biological Sciences Research Council BB/E023754/1Howard Hughes Medical InstituteNHGRI NIH HHS R01 HG004037NHGRI NIH HHS U54 HG003067NIGMS NIH HHS R01 GM069957NIGMS NIH HHS R01 GM076396NIH HHS DP1 OD003958
6 · The paper itself

Abstract

The fission yeast clade--comprising Schizosaccharomyces pombe, S. octosporus, S. cryophilus, and S. japonicus--occupies the basal branch of Ascomycete fungi and is an important model of eukaryote biology. A comparative annotation of these genomes identified a near extinction of transposons and the associated innovation of transposon-free centromeres. Expression analysis established that meiotic genes are subject to antisense transcription during vegetative growth, which suggests a mechanism for their tight regulation. In addition, trans-acting regulators control new genes within the context of expanded functional modules for meiosis and stress response. Differences in gene content and regulation also explain why, unlike the budding yeast of Saccharomycotina, fission yeasts cannot use ethanol as a primary carbon source. These analyses elucidate the genome structure and gene regulation of fission yeast and provide tools for investigation across the Schizosaccharomyces clade.

Indexed as

Genome, FungalCentromereDNA Transposable ElementsEvolution, MolecularGene Expression ProfilingGene Expression Regulation, FungalGenes, Mating Type, FungalGenomicsGlucoseMeiosisMolecular Sequence AnnotationMolecular Sequence DataPhylogenyRegulatory Elements, TranscriptionalRNA, AntisenseRNA, FungalDNA Transposable ElementsGlucoseRNA, AntisenseRNA, FungalRNA, Small InterferingRNA, UntranslatedSchizosaccharomyces pombe ProteinsTranscription Factors

Identifiers

PMID21511999
PMCPMC3131103

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.