ArticleBMC biochemistry2011
The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols.
Article in BMC biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 70 citations in OpenAlex.
- Review
- Effects of Dietary Fiber, Phenolic Compounds, and Fatty Acids on Mental Health: Possible Interactions with Genetic and Epigenetic Aspects.Nutrients · 2024Review
- Exploring epigenetic strategies for the treatment of osteoporosis.Molecular biology reports · 2024Review
- Genomic targets and selective inhibition of DNA methyltransferase isoforms.Clinical epigenetics · 2022Article
- Shared Genetics and Causality Between Decaffeinated Coffee Consumption and Neuropsychiatric Diseases: A Large-Scale Genome-Wide Cross-Trait Analysis and Mendelian Randomization Analysis.Frontiers in psychiatry · 2022Article
- Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Protocol.Pharmaceutics · 2021Article
- Expanding the Structural Diversity of DNA Methyltransferase Inhibitors.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Chromatin dynamics and histone modifications in intestinal microbiota-host crosstalk.Molecular metabolism · 2020Review
- EGCG improves recombinant protein productivity in Chinese hamster ovary cell cultures via cell proliferation control.Cytotechnology · 2018Article
- Metabolic programming of the epigenome: host and gut microbial metabolite interactions with host chromatin.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Article
- TBC2health: a database of experimentally validated health-beneficial effects of tea bioactive compounds.Briefings in bioinformatics · 2017Article
- Antioxidants from black and green tea: from dietary modulation of oxidative stress to pharmacological mechanisms.British journal of pharmacology · 2017Review
- Chemical signaling between gut microbiota and host chromatin: What is your gut really saying?The Journal of biological chemistry · 2017Review
- Specific Inhibition of DNMT3A/ISGF3γ Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth.Theranostics · 2016Article
- DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.Nature medicine · 2015Article
- A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses.Annals of botany · 2012Article
- Tea Polyphenols and Prevention of Epigenetic Aberrations in Cancer.Journal of natural science, biology, and medicineReview
- Diet, the gut microbiome, and epigenetics.Cancer journal (Sudbury, Mass.)Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBlack tea is, second only to water, the most consumed beverage globally. Previously, the inhibition of DNA methyltransferase 1 was shown by dietary polyphenols and epi-gallocatechin gallate (EGCG), the main polyphenolic constituent of green tea, and 5-caffeoyl quinic acid, the main phenolic constituent of the green coffee bean.
resultsWe studied the inhibition of DNA methyltransferase 3a by a series of dietary polyphenols from black tea such as theaflavins and thearubigins and chlorogenic acid derivatives from coffee. For theaflavin 3,3 digallate and thearubigins IC50 values in the lower micro molar range were observed, which when compared to pharmacokinetic data available, suggest an effect of physiological relevance.
conclusionsSince Dnnmt3a has been associated with development, cancer and brain function, these data suggest a biochemical mechanism for the beneficial health effect of black tea and coffee and a possible molecular mechanism for the improvement of brain performance and mental health by dietary polyphenols.
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