ReviewBMC medicine2011
Circulating tumor cells in breast cancer: a tool whose time has come of age.
Review in BMC medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients.PloS one · 2013Trial
- Enhanced Luminescent Detection of Circulating Tumor Cells by a 3D Printed Immunomagnetic Concentrator.Biosensors · 2021Article
- Detection of circulating tumor cells in blood by shell-isolated nanoparticle - enhanced Raman spectroscopy (SHINERS) in microfluidic device.Scientific reports · 2019Article
- Detection of Circulating Tumor Cells Using Membrane-Based SERS Platform: A New Diagnostic Approach for 'Liquid Biopsy'.Nanomaterials (Basel, Switzerland) · 2019Article
- Recent advances in understanding the complexities of metastasis.F1000Research · 2018Review
- Mutational studies on single circulating tumor cells isolated from the blood of inflammatory breast cancer patients.Breast cancer research and treatment · 2017Article
- Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications-Focus on Prostate and Breast Cancer.International journal of molecular sciences · 2017Review
- Establishment and Application of Prostate Cancer Circulating Tumor Cells in the Era of Precision Medicine.BioMed research international · 2017Review
- Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment.Advances in experimental medicine and biology · 2016Article
- Benchtop technologies for circulating tumor cells separation based on biophysical properties.BioMed research international · 2015Review
- Systemic chemotherapy interferes in homocysteine metabolism in breast cancer patients.Journal of clinical laboratory analysis · 2014Article
- Tumor-associated circulating microRNAs as biomarkers of cancer.Molecules (Basel, Switzerland) · 2014Review
- P-selectin-mediated platelet adhesion promotes the metastasis of murine melanoma cells.PloS one · 2014Article
- Circulating tumor cells in breast cancer.Journal of carcinogenesis · 2014Review
- Circulating tumor cell detection during chemotherapy in patients with breast cancer is not associated with plasma homocysteine levels.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Inhibition of MCF-7 breast cancer cell-induced platelet aggregation using a combination of antiplatelet drugs.Oncology letters · 2013Article
- Circulating tumor cells: a review of present methods and the need to identify heterogeneous phenotypes.Annals of clinical and laboratory science · 2013Review
- Detecting circulating tumor cells: current challenges and new trends.Theranostics · 2013Review
- Heterogeneity of ERα and ErbB2 Status in Cell Lines and Circulating Tumor Cells of Metastatic Breast Cancer Patients.Translational oncology · 2012Article
- A novel method for the in vivo isolation of circulating tumor cells from peripheral blood of cancer patients using a functionalized and structured medical wire.International journal of oncology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating tumor cells (CTCs) are isolated tumor cells disseminated from the site of disease in metastatic and/or primary cancers, including breast cancer, that can be identified and measured in the peripheral blood of patients. As recent technical advances have rendered it easier to reproducibly and repeatedly sample this population of cells with a high degree of accuracy, these cells represent an attractive surrogate marker of the site of disease. Currently, CTCs are being integrated into clinical trial design as a surrogate for phenotypic and genotypic markers in correlation with development of molecularly targeted therapies. As CTCs play a crucial role in tumor dissemination, translational research is implicating CTCs in several biological processes, including epithelial to mesenchymal transition. In this mini-review, we review CTCs in metastatic breast cancer, and discuss their clinical utility for assessing prognosis and monitoring response to therapy. We will also introduce their utility in pharmacodynamic monitoring for rational selection of molecularly targeted therapies and briefly address how they can help elucidate the biology of cancer metastasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.