Trial reportTrials2011
The International Stroke Trial database.
Trial report in Trials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Antithrombotic treatment after stroke due to intracerebral haemorrhage.The Cochrane database of systematic reviews · 2023Pooled it
- Pooled it
- Pooled it
- Antithrombotic treatment after stroke due to intracerebral haemorrhage.The Cochrane database of systematic reviews · 2017Pooled it
- Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials.The Lancet. Neurology · 2013Pooled it
- Statistical analysis plan for the 'Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage' (TICH-2) trial.Trials · 2017Trial
- Statistical analysis plan for the 'Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke' (TARDIS) trial.International journal of stroke : official journal of the International Stroke Society · 2015Trial
- Statistical analysis plan for the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial.International journal of stroke : official journal of the International Stroke Society · 2014Trial
- Machine learning methods for estimating personalized treatment effects-insights on validity from two large trials.American journal of epidemiology · 2026Article
- Evaluating Treatment Prioritization Rules via Rank-Weighted Average Treatment Effects.Journal of the American Statistical Association · 2025Article
- Understanding overfitting in random forest for probability estimation: a visualization and simulation study.Diagnostic and prognostic research · 2024Article
- Combining propensity score methods with variational autoencoders for generating synthetic data in presence of latent sub-groups.BMC medical research methodology · 2024Article
- Confounder Adjustment Using the Disease Risk Score: A Proposal for Weighting Methods.American journal of epidemiology · 2024Article
- Bayesian multilevel multivariate logistic regression for superiority decision-making under observable treatment heterogeneity.BMC medical research methodology · 2023Article
- Semi-parametric time-to-event modelling of lengths of hospital stays.Journal of the Royal Statistical Society. Series C, Applied statistics · 2022Article
- A tutorial on individualized treatment effect prediction from randomized trials with a binary endpoint.Statistics in medicine · 2021Article
- Predicting Ischemic Stroke Outcome Using Deep Learning Approaches.Frontiers in genetics · 2021Review
- The use of prognostic scores for causal inference with general treatment regimes.Statistics in medicine · 2019Article
- Statistical analysis plan for the 'Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2)'.European stroke journal · 2018Article
- UK publicly funded Clinical Trials Units supported a controlled access approach to share individual participant data but highlighted concerns.Journal of clinical epidemiology · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
backgroundWe aimed to make individual patient data from the International Stroke Trial (IST), one of the largest randomised trials ever conducted in acute stroke, available for public use, to facilitate the planning of future trials and to permit additional secondary analyses.
methodsFor each randomised patient, we have extracted data on the variables assessed at randomisation, at the early outcome point (14-days after randomisation or prior discharge) and at 6-months and provide them as an analysable database.
resultsThe IST dataset includes data on 19 435 patients with acute stroke, with 99% complete follow-up. Over 26.4% patients were aged over 80 years at study entry. Background stroke care was limited and none of the patients received thrombolytic therapy.
conclusionsThe IST dataset provides a source of primary data which could be used for planning further trials, for sample size calculations and for novel secondary analyses. Given the age distribution and nature of the background treatment given, the data may be of value in planning trials in older patients and in resource-poor settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.