ArticleRespiratory research2011
High blood pressure, antihypertensive medication and lung function in a general adult population.
Article in Respiratory research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Genome-wide association study of preserved ratio impaired spirometry (PRISm).The European respiratory journal · 2024Pooled it
- Proteomic Profiling of Pulmonary Function and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2026Observational
- Relationship between right and left ventricle function in subjects free of cardiovascular diseases: a population-based MRI study.Scientific reports · 2026Article
- Association of life's essential 8 with chronic respiratory disease mortality and lung health: a national cohort study.BMJ open respiratory research · 2026Article
- The Pilates Method reduces blood pressure and increases respiratory strength and cardiorespiratory capacity in medicated hypertensive women.European journal of applied physiology · 2025Observational
- Association between life's crucial 9 and lung health: a population-based study.BMC pulmonary medicine · 2025Article
- A Nomogram of Weaning Failure for Critical Ventilated Patients in High-Altitude Areas: A Single-Center Cohort Study Using Lasso Logistic Regression.Anesthesiology research and practice · 2025Article
- Associated Factors and Pulmonary Function Outcomes of Preserved Ratio Impaired Spirometry: A Scoping Review.International journal of chronic obstructive pulmonary disease · 2025Article
- Bidirectional Causal Association Between Chronic Obstructive Pulmonary Disease and Cardiovascular Diseases: A Mendelian Randomization Study.International journal of chronic obstructive pulmonary disease · 2024Article
- The Association of Lung Function and Carotid Intima-Media Thickness in a Japanese Population: The Tohoku Medical Megabank Community-Based Cohort Study.Journal of atherosclerosis and thrombosis · 2023Article
- Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment.Genome medicine · 2021Article
- The Effects of Asthma on the Association Between Pulmonary Function and Obesity: A 16-Year Longitudinal Study.Journal of asthma and allergy · 2021Article
- COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.GeroScience · 2020Review
- Article
- Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- Relationship between daily exposure to biomass fuel smoke and blood pressure in high-altitude Peru.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Visceral adipose tissue level, as estimated by the bioimpedance analysis method, is associated with impaired lung function.Journal of diabetes investigation · 2012Article
- Association Between Decreased Renal Function and Pulmonary Function Decline in Community-dwelling Adults.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies showed that blood pressure and lung function are associated. Additionally, a potential effect of antihypertensive medication, especially beta-blockers, on lung function has been discussed. However, side effects of beta-blockers have been investigated mainly in patients with already reduced lung function. Thus, aim of this analysis is to determine whether hypertension and antihypertensive medication have an adverse effect on lung function in a general adult population.
methodsWithin the population-based KORA F4 study 1319 adults aged 40-65 years performed lung function tests and blood pressure measurements. Additionally, information on anthropometric measurements, medical history and use of antihypertensive medication was available. Multivariable regression models were applied to study the association between blood pressure, antihypertensive medication and lung function.
resultsHigh blood pressure as well as antihypertensive medication were associated with lower forced expiratory volume in one second (p=0.02 respectively p=0.05; R2: 0.65) and forced vital capacity values (p=0.01 respectively p=0.05, R2: 0.73). Furthermore, a detailed analysis of antihypertensive medication pointed out that only the use of beta-blockers was associated with reduced lung function, whereas other antihypertensive medication had no effect on lung function. The adverse effect of beta-blockers was significant for forced vital capacity (p=0.04; R2: 0.65), while the association with forced expiratory volume in one second showed a trend toward significance (p=0.07; R2: 0.73). In the same model high blood pressure was associated with reduced forced vital capacity (p=0.01) and forced expiratory volume in one second (p=0.03) values, too.
conclusionOur analysis indicates that both high blood pressure and the use of beta-blockers, but not the use of other antihypertensive medication, are associated with reduced lung function in a general adult population.
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Registered trials
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