Evidence map›Paper›PMID 21509914›Full record

Trial reportDepression and anxiety2011

Myth of the pure obsessional type in obsessive--compulsive disorder.

Monnica T Williams, Samantha G Farris, Eric Turkheimer, Anthony Pinto, Krystal Ozanick, Martin E Franklin, Michael Liebowitz, H Blair Simpson, Edna B Foa

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Depression and anxiety, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
10.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Biomarkers of Obsessive-Compulsive Disorder Subtypes: A Literature Review.International journal of molecular sciences · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Monnica T WilliamsDepartment of Psychiatry, Center for Treatment and Study of Anxiety, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. monnica@mail.med.upenn.edu
Samantha G Farris
Eric Turkheimer
Anthony Pinto
Krystal Ozanick
Martin E Franklin
Michael Liebowitz
H Blair Simpson
Edna B Foa
University of Pennsylvania · USColumbia University · USDrexel University · USNew York Psychoanalytic Society and Institute · USNew York State Psychiatric InstituteUniversity of Virginia · US

Funding

Maximizing Treatment Outcome in OCDR01MH045404 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI FOA, EDNA B · 1990 to 2016
$5.3M
Maximizing Treatment Outcome in OCDR01MH045436 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI SIMPSON, HELEN BLAIR · 1990 to 2015
$5.0M
Phenomenology of Obsessive Compulsive Personality DisorderK23MH080221 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI PINTO, ANTHONY · 2008 to 2012
$925k
Enhancing Patient-Oriented Research and Training in OCDK24MH091555 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SIMPSON, HELEN BLAIR · 2010 to 2014
$742k
RESIDUAL IMPAIRMENT IN TREATED OCD PATIENTSR10MH045436 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE · PI LIEBOWITZ, MICHAEL R. · 1997 to 1999
–
NIMH NIH HHS K23 MH-080221NIMH NIH HHS K23 MH080221NIMH NIH HHS K24 MH091555NIMH NIH HHS R01 MH045404NIMH NIH HHS R01 MH-045404-17S1NIMH NIH HHS R01 MH045436NIMH NIH HHS R01 MH-45404NIMH NIH HHS R01 MH-45436
6 · The paper itself

Abstract

backgroundSeveral studies have identified discrete symptom dimensions in obsessive-compulsive disorder (OCD), derived from factor analyses of the individual items or symptom categories of the Yale-Brown Obsessive-Compulsive Scale Symptom Checklist (YBOCS-SC). This study aims to extend previous work on the relationship between obsessions and compulsions by specifically including mental compulsions and reassurance-seeking. Because these compulsions have traditionally been omitted from prior factor analytic studies, their association to what have been called "pure obsessions" may have been overlooked.

methodParticipants (N = 201) were recruited from two multi-site randomized clinical treatment trials for OCD. The YBOCS-SC was used to assess OCD symptoms, as it includes a comprehensive list of obsessions and compulsions, arranged by content category. Each category was given a score based on whether symptoms were present and if the symptom was a primary target of clinical concern, and a factor analysis was conducted. Mental compulsions and reassurance-seeking were considered separate categories for the analysis.

resultsUsing an orthogonal geomin rotation of 16 YBOCS-SC categories/items, we found a five-factor solution that explained 67% of the total variance. Inspection of items that composed each factor suggests five familiar constructs, with mental compulsions and reassurance-seeking included with sexual, aggressive, and religious obsessions (unacceptable/taboo thoughts).

conclusionsThis study suggests that the concept of the "pure obsessional" (e.g., patients with unacceptable/taboo thoughts yet no compulsions) may be a misnomer, as these obsessions were factorially associated with mental compulsions and reassurance-seeking in these samples. These findings may have implications for DSM-5 diagnostic criteria.

Indexed as

AdultCeremonial BehaviorClomipramineCognitive Behavioral TherapyCombined Modality TherapyFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderPersonality AssessmentSelective Serotonin Reuptake InhibitorsTabooThinkingClomipramineSelective Serotonin Reuptake Inhibitors

Identifiers

PMID21509914
PMCPMC3227121
OpenAlexW2129374538

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.