ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
Self-reported weight at birth predicts measures of femoral size but not volumetric BMD in eldery men: MrOS.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Placental Size Is Associated Differentially With Postnatal Bone Size and Density.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Trial
- Are birth characteristics related to bone quality measures in young adults? The HUNT study, Norway.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Birth weight influences differently on systolic and diastolic blood pressure in children and adolescents aged 8-15.BMC pediatrics · 2022Article
- Childhood growth predicts higher bone mass and greater bone area in early old age: findings among a subgroup of women from the Helsinki Birth Cohort Study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Developmental aspects of a life course approach to healthy ageing.The Journal of physiology · 2016Review
- Article
- Growth from birth to adulthood and bone phenotype in early old age: a British birth cohort study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- New insights into osteoporosis: the bone-fat connection.Journal of internal medicine · 2012Review
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Authors and funding
13 authors at 7 institutions in 3 countries.
Funding
Abstract
The mechanism whereby poor intrauterine growth increases risk of adult hip fracture is unclear. We report the association between birth weight and proximal femoral geometry and density in community-dwelling elderly men. We used self-reported birth weight, measured adult height and weight and proximal femoral quantitative computed tomography (QCT) measurements of femoral neck axis length, cross-sectional area, and volumetric BMD (vBMD) among the participants in the Osteoporotic Fractures in Men (MrOS), a cohort study of community-dwelling US men aged 65 and older. We compared men with birth weight <7 pounds (lower birth weight [LBW]; n = 501) and ≥ 9 pounds (higher birth weight [HBW]; n = 262) with those weighing 7-8.9 pounds (medium birth weight [MBW], referent group; n = 1068) using linear regression adjusting for current age, height, and BMI. The mean age of the 1831 men who had both birth weight and QCT measurements was 73 years (SD 5.9). Compared with the referent MBW, HBW men had concordantly longer femoral neck (+0.16 SD; p = .028) and cross-sectional area (+0.24 SD, p = .001). LBW men had a smaller cross-sectional (-0.26 SD, p < .001) but longer femoral neck for their height (+0.11 SD, p = .05). Neither cortical nor trabecular vBMD at the femoral neck was associated with birth weight. These findings support the hypothesis that the skeletal envelope, but not density, is set, in part, at birth. Further research exploring the association between early developmental factors and lifetime fracture risk is needed and may inform primary preventative strategies for fracture prevention.
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Registered trials
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