ArticleCancer2011
Late age at first full term birth is strongly associated with lobular breast cancer.
Article in Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Genetic and lifestyle factors for breast cancer risk assessment in Southeast China.Cancer medicine · 2023Trial
- The association between parity, age of first full term pregnancy and invasive lobular breast cancer: a case-only analysis.Cancer treatment and research communications · 2026Article
- Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?Endocrinology · 2024Review
- Reproductive history differs by molecular subtypes of breast cancer among women aged ≤ 50 years in Scotland diagnosed 2009-2016: a cross-sectional study.Breast cancer research and treatment · 2022Article
- Multivariate analysis of independent roles of socioeconomic status, occupational physical activity, reproductive factors, and postmenopausal hormonal therapy in risk of breast cancer.Breast cancer research and treatment · 2022Article
- A genome-wide gene-based gene-environment interaction study of breast cancer in more than 90,000 women.Cancer research communications · 2022Article
- Chemopreventive and Anticancer Property of Selenoproteins in Obese Breast Cancer.Frontiers in pharmacology · 2021Review
- Intraoperative photoacoustic screening of breast cancer: a new perspective on malignancy visualization and surgical guidance.Journal of biomedical optics · 2019Article
- Overview of the genetic basis toward early detection of breast cancer.Breast cancer (Dove Medical Press) · 2019Review
- Enzymatic Antioxidant and Lipid Peroxidation Evaluation in the Newly Diagnosed Breast Cancer Patients in IranAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Reproductive risk factor associations with lobular and ductal carcinoma in the Carolina Breast Cancer Study.Cancer causes & control : CCC · 2018Article
- Emerging Trends in Family History of Breast Cancer and Associated Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2017Article
- Cigarette Smoking Before and After Breast Cancer Diagnosis: Mortality From Breast Cancer and Smoking-Related Diseases.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Observational
- Variation in Breast Cancer-Risk Factor Associations by Method of Detection: Results From a Series of Case-Control Studies.American journal of epidemiology · 2015Article
- Lobular breast cancer: incidence and genetic and non-genetic risk factors.Breast cancer research : BCR · 2015Review
- Triple-negative breast cancer risk in women is defined by the defect of estrogen signaling: preventive and therapeutic implications.OncoTargets and therapy · 2014Article
- Mimicking pregnancy as a strategy for breast cancer prevention.Breast cancer management · 2013Article
- Alcohol consumption before and after breast cancer diagnosis: associations with survival from breast cancer, cardiovascular disease, and other causes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
- Circulatory estrogen level protects against breast cancer in obese women.Recent patents on anti-cancer drug discovery · 2013Review
- Do reproductive factors influence T, N, and M classes of ductal and lobular breast cancers? A nation-wide follow-up study.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundLate age at first full-term birth and nulliparity are known to increase breast cancer risk. The frequency of these risk factors has increased in recent decades.
methodsThe purpose of this population-based case-control study was to examine associations between parity, age at first birth (AFB), and specific histological subtypes of breast cancer. Women with breast cancer were identified from cancer registries in Wisconsin, Massachusetts, and New Hampshire. Control subjects were randomly selected from population lists. Interviews collected information on reproductive histories and other risk factors. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of ductal, lobular, and mixed ductal-lobular breast cancer diagnosis in association with AFB and nulliparity.
resultsAFB ≥30 years was associated with a 2.4-fold increase in risk of lobular breast cancer compared with AFB <20 years (OR, 2.4; 95% CI, 1.9-2.9). The association was less pronounced for ductal breast cancer (OR, 1.3; 95% CI, 1.2-1.4). Nulliparity was associated with increased risk for all breast cancer subtypes, compared with women with AFB <20 years, but the association was stronger for lobular (OR, 1.7; 95% CI, 1.3-2.2) than for ductal (OR, 1.2; 95% CI, 1.1-1.3) subtypes (P = .004). The adverse effects of later AFB was stronger with obesity (P = .03) in lobular, but not ductal, breast cancer.
conclusionsStronger associations observed for late AFB and nulliparity suggest that these factors preferentially stimulate growth of lobular breast carcinomas. Recent temporal changes in reproductive patterns and rates of obesity may impact the histological presentation of breast cancer.
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