ArticleEuropean archives of psychiatry and clinical neuroscience2012
Association of the brain-derived neurotrophic factor val66met polymorphism with magnetic resonance spectroscopic markers in the human hippocampus: in vivo evidence for effects on the glutamate system.
Article in European archives of psychiatry and clinical neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Glutamatergic and N-Acetylaspartate Metabolites in Bipolar Disorder: A Systematic Review and Meta-Analysis of Proton Magnetic Resonance Spectroscopy Studies.International journal of molecular sciences · 2022Pooled it
- Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism and Risk of Schizophrenia: A Meta-analysis of Case-Control Studies.Cellular and molecular neurobiology · 2016Pooled it
- Association between brain-derived neurotrophic factor genetic polymorphism Val66Met and susceptibility to bipolar disorder: a meta-analysis.BMC psychiatry · 2014Pooled it
- Longitudinal markers of cognitive procedural learning in fronto-striatal circuits and putative effects of a BDNF plasticity-related variant.NPJ science of learning · 2024Article
- BDNF rs6265 differentially influences neurometabolites in the anterior cingulate of healthy and bipolar disorder subjects.Brain imaging and behavior · 2023Article
- Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts.Scientific reports · 2021Article
- Influence of Brain-Derived Neurotrophic Factor Genotype on Short-Latency Afferent Inhibition and Motor Cortex Metabolites.Brain sciences · 2021Article
- BDNF genotype is associated with hippocampal volume in mild traumatic brain injury.Genes, brain, and behavior · 2018Article
- Article
- Polymorphism of the brain-derived neurotrophic factor and dynamics of the seizure threshold of electroconvulsive therapy.European archives of psychiatry and clinical neuroscience · 2017Article
- Diagnosis and body mass index effects on hippocampal volumes and neurochemistry in bipolar disorder.Translational psychiatry · 2017Article
- Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in Schizophrenia.Frontiers in psychiatry · 2017Article
- BDNF val66met polymorphism affects aging of multiple types of memory.Brain research · 2015Article
- BDNF-Val66Met-polymorphism impact on cortical plasticity in schizophrenia patients: a proof-of-concept study.The international journal of neuropsychopharmacology · 2014Article
- Glutamate-mediated excitotoxicity in schizophrenia: a review.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2014Review
- Brain proton magnetic resonance spectroscopy of alcohol use disorders.Handbook of clinical neurology · 2014Review
- Neural activation in humans during a simple motor task differs between BDNF polymorphisms.PloS one · 2014Article
- Article
- Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T.European archives of psychiatry and clinical neuroscience · 2013Article
- Schizophrenia: brain morphology and treatment aspects.European archives of psychiatry and clinical neuroscience · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain-derived neurotrophic factor (BDNF) is a key regulator of synaptic plasticity and has been suggested to be involved in the pathophysiology and pathogenesis of psychotic disorders, with particular emphasis on dysfunctions of the hippocampus. The aim of the present study was to replicate and to extend prior findings of BDNF val66met genotype effects on hippocampal volume and N-acetyl aspartate (NAA) levels. Hundred and fifty-eight caucasians (66 schizophrenic, 45 bipolar, and 47 healthy subjects; 105 subjects underwent MRI and 103 MRS scanning) participated in the study and were genotyped with regard to the val66met polymorphism (rs6265) of the BDNF gene. Hippocampal volumes were determined using structural magnetic resonance imaging (MRI), and measures of biochemical markers were taken using proton magnetic resonance spectroscopy ((1)H-MRS) in the hippocampus and other brain regions. Verbal memory was assessed as a behavioral index of hippocampal function. BDNF genotype did not impact hippocampal volumes. Significant genotype effects were found on metabolic markers specifically in the left hippocampus. In particular, homozygous carriers of the met-allele exhibited significantly lower NAA/Cre and (Glu + Gln)/Cre metabolic ratios compared with val/val homozygotes, independently of psychiatric diagnoses. BDNF genotype had a numerical, but nonsignificant effect on verbal memory performance. These findings provide first in vivo evidence for an effect of the functional BDNF val66met polymorphism on the glutamate system in human hippocampus.
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