ArticleClinical and experimental nephrology2011
Measurements of serum cystatin C concentrations underestimate renal dysfunction in pediatric patients with chronic kidney disease.
Article in Clinical and experimental nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Cystatin C-based equation for estimating glomerular filtration rate in Japanese children and adolescents.Clinical and experimental nephrology · 2014Trial
- Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0-18 years old).The Journal of international medical research · 2019Article
- Comparison of glomerular filtration rates calculated by different serum cystatin C-based equations in patients with chronic kidney disease.Kidney research and clinical practice · 2014Article
- Reference intervals of serum cystatin C/creatinine ratio of 30 postnatal days in neonates.Pediatric nephrology (Berlin, Germany) · 2014Article
- Validity of cystatin C/creatinine ratio in pediatric kidney disease.Clinical and experimental nephrology · 2012Article
- Cystatin C/creatinine ratio in pediatric kidney disease.Clinical and experimental nephrology · 2011Article
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Authors and funding
11 authors.
Funding
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Abstract
backgroundIn our clinical experience, cystatin C (CysC) concentrations are not as high as expected in patients with chronic kidney disease (CKD) and high-stage renal dysfunction. We therefore investigated whether measurements of serum CysC result in an underestimation of renal dysfunction in pediatric patients with CKD.
methodsGlomerular filtration rate (GFR) was estimated from serum creatinine (Cr) concentration, using the equation Cr-GFR (%) = [0.30 × body length (m)/serum Cr] × 100; and from serum CysC concentration, using the equation Cys-GFR (%) = (0.70/serum CysC) × 100. We investigated the relationship between GFR estimated by these 2 equations. Patients aged 2-12 years were assorted into 5 groups, based on GFR-Cr categories of <12.5, ≥12.5 to <25, ≥25 to <50, ≥50 to <75, and ≥75%, and GFR-CysC/GFR-Cr ratios were compared in these 5 groups.
resultsThe median GFR-CysC/GFR-Cr ratio in groups of patients with GFR-Cr of <12.5, ≥12.5 to <25, ≥25 to <50, ≥50 to <75, and ≥75% were 2.28, 1.48, 1.22, 1.18 and 0.98, respectively, with statistically significant differences between any two groups (p < 0.001).
conclusionMeasurements of serum CysC concentrations lead to underestimation of renal dysfunction in pediatric patients with CKD.
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