ArticleCommunicative & integrative biology2011
Cell adhesion signaling pathways: First responders to cocaine exposure?
Article in Communicative & integrative biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- Transcriptomics of Environmental Enrichment Reveals a Role for Retinoic Acid Signaling in Addiction.Frontiers in molecular neuroscience · 2016Article
- Synaptic Cytoskeletal Plasticity in the Prefrontal Cortex Following Psychostimulant Exposure.Traffic (Copenhagen, Denmark) · 2015Review
- Environmental enrichment alters protein expression as well as the proteomic response to cocaine in rat nucleus accumbens.Frontiers in behavioral neuroscience · 2014Article
- Developmentally divergent effects of Rho-kinase inhibition on cocaine- and BDNF-induced behavioral plasticity.Behavioural brain research · 2013Article
- Low prefrontal PSA-NCAM confers risk for alcoholism-related behavior.Nature neuroscience · 2012Article
- Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Aberrant learning and memory in addiction.Neurobiology of learning and memory · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The 100 billion neurons comprising the human brain are wired together using structural extensions termed axons, dendrites and dendritic spines. Addictive drugs remodel dendritic spine structure in certain brain regions and with repeated exposure, induce psychomotor sensitization and impair behavioral flexibility. We recently reported that low-dose cocaine exposure, in combination with knockout of Arg-an adhesion-regulated nonreceptor tyrosine kinase that stabilizes neuronal shape starting in adolescence-recapitulates both features of chronic drug exposure in rodents. In light of these and other recent findings in the field, we suggest that cell adhesion receptors and their downstream cytoskeletal effectors act as "first responders" to psychostimulant exposure. In this model, cell adhesion factors act to stabilize existing dendritic spines in response to cocaine, and reduced expression/function is expected to increase vulnerability. Moreover, this model anticipates that increased sensitivity to psychostimulants in adolescence relates to neuronal pruning processes that occur during this developmental period.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.