Evidence map›Paper›PMID 21508982›Full record

ReviewNature reviews. Immunology2011

Illuminating viral infections in the nervous system.

Dorian B McGavern, Silvia S Kang

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 276 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Immune signaling and function in neurodegeneration.The Journal of clinical investigation · 2026
    Review
  7. Review
  8. Exploring the role of infectious pathogens in Alzheimer's disease neuroinflammation.Frontiers in cellular and infection microbiology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Dorian B McGavernNational Institute of Neurological Disorders and Stroke, The National Institutes of Health, Bethesda, Maryland 20892, USA. mcgavernd@mail.nih.gov
Silvia S Kang
National Institute of Neurological Disorders and Stroke · USNational Institutes of Health · US

Funding

Pathogenesis of viral meningitisZIANS003112 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.6M
Mechanisms Underlying Clearance of the Persistently Infected CNSZIANS003111 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.0M
Dynamics of Cytotoxic Lymphocyte-Glial Interactions During Acute MeningitisF32NS061447 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI KANG, SILVIA · 2008 to 2008
$29k
Intramural NIH HHS ZIA NS003111NINDS NIH HHS F32 NS061447NINDS NIH HHS NS061447‑01
6 · The paper itself

Abstract

Viral infections are a major cause of human disease. Although most viruses replicate in peripheral tissues, some have developed unique strategies to move into the nervous system, where they establish acute or persistent infections. Viral infections in the central nervous system (CNS) can alter homeostasis, induce neurological dysfunction and result in serious, potentially life-threatening inflammatory diseases. This Review focuses on the strategies used by neurotropic viruses to cross the barrier systems of the CNS and on how the immune system detects and responds to viral infections in the CNS. A special emphasis is placed on immune surveillance of persistent and latent viral infections and on recent insights gained from imaging both protective and pathogenic antiviral immune responses.

Indexed as

AnimalsBlood-Brain BarrierBlood-Nerve BarrierCapillary PermeabilityCentral Nervous SystemCentral Nervous System Viral DiseasesEndothelium, VascularHumansPeripheral Nervous SystemVirusesVirus InternalizationVirus Latency

Identifiers

PMID21508982
PMCPMC5001841
OpenAlexW2059369279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.