ArticleTransplantation2011
Recurrent glomerulonephritis under rapid discontinuation of steroids.
Article in Transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Are We Winning at Twinning? Persistent CNI Use in Identical Kidney Transplants.Clinical transplantation · 2026Article
- Early Steroid Withdrawal in Kidney Transplant Recipients: CON.Kidney360 · 2025Article
- A review of landmark studies on maintenance immunosuppressive regimens in kidney transplantation.Asian biomedicine : research, reviews and news · 2024Review
- UNOS/OPTN Data-guided Assessment of Focal Segmental Glomerulosclerosis After Kidney Transplantation and Evaluation of Immunosuppressive Protocols in a Steroid-free Center.Transplantation direct · 2021Article
- Individual Lymphocyte Sensitivity to Steroids as a Reliable Biomarker for Clinical Outcome after Steroid Withdrawal in Japanese Renal Transplantation.Journal of clinical medicine · 2021Article
- The association of acute rejection vs recurrent glomerular disease with graft outcomes after kidney transplantation.Clinical transplantation · 2019Article
- Etiological analysis of graft dysfunction following living kidney transplantation: a report of 366 biopsies.Renal failure · 2018Article
- Recurrence of IgA nephropathy after kidney transplantation in steroid continuation versus early steroid-withdrawal regimens: a retrospective analysis of the UNOS/OPTN database.Transplant international : official journal of the European Society for Organ Transplantation · 2018Article
- Recurrent and de novo glomerulonephritis following renal transplantation: higher rates of rejection and lower graft survival.International urology and nephrology · 2017Article
- Kidney Transplantation Outcomes across GN Subtypes in the United States.Journal of the American Society of Nephrology : JASN · 2017Article
- Corticosteroid minimization in renal transplantation: Careful patient selection enables feasibility.World journal of transplantation · 2016Article
- Treatment protocol with pulse and oral steroids for IgA Nephropathy after kidney transplantation.Journal of nephrology · 2016Article
- Graft loss due to recurrent disease in pediatric kidney transplant recipients on a rapid prednisone discontinuation protocol.Pediatric transplantation · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecurrent glomerulonephritis (GN) remains an important cause of kidney allograft loss and whether rapid discontinuation of steroids (RDS) is associated with a higher risk of recurrence is not known.
methodsWe studied recurrence rate, and graft and patient survival in four groups of recipients: 216 recipients with GN transplanted under RDS (group 1), 978 concurrent non-GN recipients transplanted under RDS (group 2), 260 historic comparator group transplanted for GN between 1994 and 1999 with steroid maintenance (group 3), and 950 recipients who were also transplanted between 1994 and 1999 for non-GN and also maintained on steroids (group 4). Regression analysis adjusting for donor and recipient factors, steroid and sirolimus use, and also GN type was used to address factors associated with recurrent disease.
resultsThe 1-, 5-, and 7-year recurrence rate in the GN group under RDS was 6.7%, 13.7%, and 19.2% and in historic GN recipients maintained on steroids it was 2.4%, 3.8%, and 5.3%, respectively (P<0.0001). RDS was associated with a higher adjusted risk of recurrent disease for all GN types (hazard ratio 4.86; 95% confidence interval 2.34-10.07; P<0.0001). Graft and patient survival were similar in the two GN groups and both were highest among all groups. Notably, death-censored graft survival was not different among the groups.
conclusionSteroid avoidance may be associated with a higher rate of recurrent GN but no apparent increase in risk of graft loss. This group of recipients needs to be studied more carefully, in larger numbers, and for a longer time period.
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Registered trials
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