ArticleObstetrics and gynecology2011
Admixture mapping to identify spontaneous preterm birth susceptibility loci in African Americans.
Article in Obstetrics and gynecology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of interleukin-6 polymorphism on risk of preterm birth within population strata: a meta-analysis.BMC genetics · 2013Pooled it
- Genetic variation associated with preterm birth in African-American women.American journal of obstetrics and gynecology · 2016Trial
- Systematic review of preterm birth multi-omic biomarker studies.Expert reviews in molecular medicine · 2022Review
- Racial/Ethnic Representation in United States and Australian Obstetric Research.Maternal and child health journal · 2021Review
- Accounting for diverse evolutionary forces reveals mosaic patterns of selection on human preterm birth loci.Nature communications · 2020Article
- Racial and ethnic differences in preterm birth: A complex, multifactorial problem.Seminars in perinatology · 2017Review
- Differential effects of stress and African ancestry on preterm birth and related traits among US born and immigrant Black mothers.Medicine · 2017Observational
- Admixture Mapping of African-American Women in the AMBER Consortium Identifies New Loci for Breast Cancer and Estrogen-Receptor Subtypes.Frontiers in genetics · 2016Article
- Insights into genetic susceptibility in the etiology of spontaneous preterm birth.The application of clinical genetics · 2015Review
- The contribution of genetic and environmental factors to the duration of pregnancy.American journal of obstetrics and gynecology · 2014Review
- Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth prevention.American journal of obstetrics and gynecology · 2014Article
- Finding a place for genomics in health disparities research.Public health genomics · 2012Article
- Premature delivery and the millennium development goal.Reviews in obstetrics & gynecology · 2012Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectivePreterm birth is 1.5 times more common in African American (17.8%) than European American women (11.5%), even after controlling for confounding variables. We hypothesize that genetic factors may account for this disparity and can be identified by admixture mapping.
methodsThis is a secondary analysis of women with at least one prior spontaneous preterm birth enrolled in a multicenter prospective study. DNA was extracted and whole-genome amplified from stored saliva samples. Self-identified African American patients were genotyped with a 1,509 single nucleotide polymorphism (SNP) commercially available admixture panel. A logarithm of odds locus-genome score of 1.5 or higher was considered suggestive and 2 or higher was considered significant for a disease locus.
resultsOne hundred seventy-seven African American women with one or more prior spontaneous preterm births were studied. One thousand four hundred fifty SNPs were in Hardy-Weinberg equilibrium and passed quality filters. Individuals had a mean of 78.3% to 87.9% African American ancestry for each SNP. A locus on chromosome 7q21-22 was suggestive of an association with spontaneous preterm birth before 37 weeks of gestation (three SNPs with logarithm of odds scores 1.50-1.99). This signal strengthened when women with at least one preterm birth before 35.0 (eight SNPs with logarithm of odds scores greater than 1.50) and before 32.0 weeks of gestation were considered (15 SNPs with logarithm of odds scores greater than 1.50). No other areas of the genome had logarithm of odds scores higher than 1.5.
conclusionSpontaneous preterm birth in African American women may be genetically mediated by a susceptibility locus on chromosome 7. This region contains multiple potential candidate genes, including collagen type 1-α-2 gene and genes involved with calcium regulation.
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