ArticleRNA biology
CUG-binding protein represses translation of p27Kip1 mRNA through its internal ribosomal entry site.
Article in RNA biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- High-Throughput Transcriptomics ofCells · 2023Article
- An Unanticipated Modulation of Cyclin-Dependent Kinase Inhibitors: The Role of Long Non-Coding RNAs.Cells · 2022Review
- CELF1 promotes matrix metalloproteinases gene expression at transcriptional level in lens epithelial cells.BMC ophthalmology · 2022Article
- The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development.Human genetics · 2020Article
- Increased nuclear but not cytoplasmic activities of CELF1 protein leads to muscle wasting.Human molecular genetics · 2020Article
- Comprehensive analysis of circRNA expression profiles and circRNA-associated competing endogenous RNA networks in the development of mouse thymus.Journal of cellular and molecular medicine · 2020Article
- Article
- IRES Trans-Acting Factors, Key Actors of the Stress Response.International journal of molecular sciences · 2019Review
- Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1.Nucleic acids research · 2018Article
- The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development.PLoS genetics · 2018Article
- Induction of Apoptosis and Cell Cycle Arrest by Flavokawain C on HT-29 Human Colon Adenocarcinoma via Enhancement of Reactive Oxygen Species Generation, Upregulation of p21, p27, and GADD153, and Inactivation of Inhibitor of Apoptosis Proteins.Pharmacognosy magazine · 2017Article
- CUG-binding protein 1 (CUGBP1) expression and prognosis of brain metastases from non-small cell lung cancer.Thoracic cancer · 2016Article
- NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation.Aging · 2015Article
- The Expression of CUGBP1 After Spinal Cord Injury in Rats.Neurochemical research · 2015Article
- Overexpression of CUGBP1 is associated with the progression of non-small cell lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- CUGBP1 promotes cell proliferation and suppresses apoptosis via down-regulating C/EBPα in human non-small cell lung cancers.Medical oncology (Northwood, London, England) · 2015Article
- CELF1 is Up-Regulated in Glioma and Promotes Glioma Cell Proliferation by Suppression of CDKN1B.International journal of biological sciences · 2015Article
- Si-RNA mediated knockdown of CELF1 gene suppressed the proliferation of human lung cancer cells.Cancer cell international · 2013Article
- CUG-binding protein 1 (CUGBP1) expression and prognosis of non-small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2013Article
- microRNAs and RNA-binding proteins: a complex network of interactions and reciprocal regulations in cancer.RNA biology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The cyclin dependent kinase inhibitor p27 (Kip1) plays an important role in controlling the eukaryotic cell cycle. The 5'-untranslated region of the p27 mRNA harbors an internal ribosome entry site (IRES) which may facilitate synthesis of p27 in certain conditions. In this study, the RNA-associated protein CUGBP1 was shown to interact with the human p27 5'-untranslated region. Overexpression of CUGBP1 inhibited endogenous p27 expression and reduced translation initiation through the p27 IRES. In contrast, repression of CUGBP1 by siRNA transfection enhanced p27 protein levels and stimulated p27 IRES activity. Addition of recombinant CUGBP1 repressed p27 IRES reporter mRNA translation in vitro. At last, Our finding showed that cytosolic form of CUGBP1 binds efficiently to the p27 5'-untranslated region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.