ArticleMolecular biology of the cell2011
Scc2 regulates gene expression by recruiting cohesin to the chromosome as a transcriptional activator during yeast meiosis.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- The dynamic pool of Rec8-cohesin is crucial for meiotic recombination and transcription regulation in the yeast Saccharomyces cerevisiae.The Journal of biological chemistry · 2026Article
- Crosstalk between cohesins and axis proteins determines meiotic chromosome architecture in Sordaria macrospora.PLoS genetics · 2025Article
- Functions of cyclins and CDKs in mammalian gametogenesis†.Biology of reproduction · 2019Review
- The nature of meiotic chromosome dynamics and recombination in budding yeast.Journal of microbiology (Seoul, Korea) · 2019Review
- Methods for Controlled Protein Depletion to Study Protein Function during Meiosis.Methods in enzymology · 2018Article
- A Dual-Color Reporter Assay of Cohesin-Mediated Gene Regulation in Budding Yeast Meiosis.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Identification of Functional Domains in the Cohesin Loader Subunit Scc4 by a Random Insertion/Dominant Negative Screen.G3 (Bethesda, Md.) · 2016Article
- Complex elaboration: making sense of meiotic cohesin dynamics.The FEBS journal · 2015Review
- Condensin suppresses recombination and regulates double-strand break processing at the repetitive ribosomal DNA array to ensure proper chromosome segregation during meiosis in budding yeast.Molecular biology of the cell · 2014Article
- Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I.Chromosoma · 2014Article
- Cell cycle-specific cleavage of Scc2 regulates its cohesin deposition activity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Inactivation of the budding yeast cohesin loader Scc2 alters gene expression both globally and in response to a single DNA double strand break.Cell cycle (Georgetown, Tex.) · 2014Article
- Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase.Cell division · 2013Article
- Multiple opposing constraints govern chromosome interactions during meiosis.PLoS genetics · 2013Article
- A unique role of cohesin-SA1 in gene regulation and development.The EMBO journal · 2012Article
- Tracking chromosome dynamics in live yeast cells: coordinated movement of rDNA homologs and anaphase disassembly of the nucleolus during meiosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Cohesin: a catenase with separate entry and exit gates?Nature cell biology · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To tether sister chromatids, a protein-loading complex, including Scc2, recruits cohesin to the chromosome at discrete loci. Cohesin facilitates the formation of a higher-order chromosome structure that could also influence gene expression. How cohesin directly regulates transcription remains to be further elucidated. We report that in budding yeast Scc2 is required for sister-chromatid cohesion during meiosis for two reasons. First, Scc2 is required for activating the expression of REC8, which encodes a meiosis-specific cohesin subunit; second, Scc2 is necessary for recruiting meiotic cohesin to the chromosome to generate sister-chromatid cohesion. Using a heterologous reporter assay, we have found that Scc2 increases the activity of its target promoters by recruiting cohesin to establish an upstream cohesin-associated region in a position-dependent manner. Rec8-associated meiotic cohesin is required for the full activation of the REC8 promoter, revealing that cohesin has a positive feedback on transcriptional regulation. Finally, we provide evidence that chromosomal binding of cohesin is sufficient for target-gene activation during meiosis. Our data support a noncanonical role for cohesin as a transcriptional activator during cell differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.