ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Genomewide analysis of rat barrel cortex reveals time- and layer-specific mRNA expression changes related to experience-dependent plasticity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- Molecular states underlying neuronal cell type development and plasticity in the postnatal whisker cortex.PLoS biology · 2025Article
- Molecular states underlying neuronal cell type development and plasticity in the whisker cortex.bioRxiv : the preprint server for biology · 2024Article
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- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- BDNF Therapeutic Mechanisms in Neuropsychiatric Disorders.International journal of molecular sciences · 2022Review
- Experience-dependent plasticity in early stations of sensory processing in mature brains: effects of environmental enrichment on dendrite measures in trigeminal nuclei.Brain structure & function · 2022Article
- A unique bipartite Polycomb signature regulates stimulus-response transcription during development.Nature genetics · 2021Article
- Neuronal Activity Regulates Blood-Brain Barrier Efflux Transport through Endothelial Circadian Genes.Neuron · 2020Article
- Impacts of Sleep Loss versus Waking Experience on Brain Plasticity: Parallel or Orthogonal?Trends in neurosciences · 2020Review
- Temporal Profile of Brain Gene Expression After Prey Catching Conditioning in an Anuran Amphibian.Frontiers in neuroscience · 2019Article
- The Stress-Induced Transcription Factor NR4A1 Adjusts Mitochondrial Function and Synapse Number in Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Glutamatergic System in Primary Somatosensory Neurons and Its Involvement in Sensory Input-Dependent Plasticity.International journal of molecular sciences · 2017Review
- Optimization of Experimental Parameters in Data-Independent Mass Spectrometry Significantly Increases Depth and Reproducibility of Results.Molecular & cellular proteomics : MCP · 2017Article
- Article
- Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants: Randomized Controlled Trial.JMIR research protocols · 2017Article
- Article
- Sensory Input-Dependent Changes in Glutamatergic Neurotransmission- Related Genes and Proteins in the Adult Rat Trigeminal Ganglion.Frontiers in molecular neuroscience · 2016Article
- Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity.Frontiers in neuroscience · 2015Article
- Npas4 expression in two experimental models of the barrel cortex plasticity.Neural plasticity · 2015Article
- Genomewide analysis of rat periaqueductal gray-dorsal horn reveals time-, region- and frequency-specific mRNA expression changes in response to electroacupuncture stimulation.Scientific reports · 2014Article
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6 authors.
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Abstract
Because of its anatomical organization, the rodent whisker-to-barrel system is an ideal model to study experience-dependent plasticity. Manipulation of sensory input causes changes in the properties of the barrels at the physiological, structural, and functional levels. However, much less is known about the molecular events underlying these changes. To explore such molecular events, we have used a genomewide approach to identify key genes and molecular pathways involved in experience-induced plasticity in the barrel cortex of adult rats. Given the natural tendency of rats to explore novel objects, exposure to an enriched environment (EE) was used to stimulate the activity of the whisker-to-barrel cortex in vivo. Microarray analysis at two different time points after EE revealed differential expression of genes encoding transcription factors, including nuclear receptors, as well as of genes involved in the regulation of synaptic plasticity, cell differentiation, metabolism, and, surprisingly, blood vessel morphogenesis. These expression differences reflect changes in somatosensory information processing because unilateral whisker clipping showed EE-induced differential expression patterns in the spared versus deprived barrel cortex. Finally, in situ hybridization revealed cortical layer patterns specific for each selected gene. Together, the present study offers the first genomewide exploration of the key genes regulated by somatosensory stimulation in the barrel cortex and thus provides a solid experimental framework for future in-depth analysis of the mechanisms underlying experience-dependent plasticity.
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