ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Hippocampal Astrocytes Impact Postnatal Development of Inhibitory Connections, Parvalbumin Levels, Social, and Spatial Navigation Behaviors in a Mouse Model of Fragile X Syndrome.Journal of neurochemistry · 2026Article
- Innervation Pattern of Inhibitory Projection Neurons in the Bird Sound Localization Circuit.The Journal of comparative neurology · 2026Article
- Distinct Patterns of Evoked Firing in Engram and Non-Engram Neurons in the Dentate Gyrus of Hippocampal Slices.Hippocampus · 2025Article
- Established and emerging GABAFrontiers in pharmacology · 2024Review
- GABA tone regulation and its cognitive functions in the brain.Nature reviews. Neuroscience · 2023Review
- Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum.International journal of molecular sciences · 2023Review
- Tonotopic differentiation of presynaptic neurotransmitter-releasing machinery in the auditory brainstem during the prehearing period and its selective deficits in Fmr1 knockout mice.The Journal of comparative neurology · 2022Article
- Cellular Strategies for Frequency-Dependent Computation of Interaural Time Difference.Frontiers in synaptic neuroscience · 2022Review
- Extracellular GABA waves regulate coincidence detection in excitatory circuits.The Journal of physiology · 2020Article
- Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem.Frontiers in neural circuits · 2020Review
- GABA is a modulator, rather than a classical transmitter, in the medial nucleus of the trapezoid body-lateral superior olive sound localization circuit.The Journal of physiology · 2019Article
- The Functional Role of Spontaneously Opening GABAFrontiers in molecular neuroscience · 2019Article
- Postsynaptic FMRP Regulates SynaptogenesisThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Anatomy and Physiology of Metabotropic Glutamate Receptors in Mammalian and Avian Auditory System.HSOA trends in anatomy and physiology · 2018Article
- Intrinsic physiology of inhibitory neurons changes over auditory development.Journal of neurophysiology · 2018Article
- Chronic Gestational Exposure to Ethanol Leads to Enduring Aberrances in Cortical Form and Function in the Medial Prefrontal Cortex.Alcoholism, clinical and experimental research · 2016Article
- Depolarizing GABA/glycine synaptic events switch from excitation to inhibition during frequency increases.Scientific reports · 2016Article
- Phasic and Tonic Inhibition are Maintained Respectively by CaMKII and PKA in the Rat Visual Cortex.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2014Article
- Metabotropic glutamate receptors in auditory processing.Neuroscience · 2014Review
- Glycinergic inhibition tunes coincidence detection in the auditory brainstem.Nature communications · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has emerged as a novel form of neural inhibition in the CNS. However, little is known about its presence and function in the auditory system. Using whole-cell recordings in brain slices, we identified a tonic current mediated by GABA(A)Rs containing the δ subunit in middle/high-characteristic-frequency neurons of the chicken nucleus laminaris, the first interaural time difference encoder that computes information for sound localization. This tonic conductance was activated by ambient concentrations of GABA released from synaptic vesicles. Furthermore, pharmacological manipulations of the conductance demonstrated its essential role in coincidence detection. Remarkably, this depolarizing tonic conductance was strongly inhibitory primarily because of its shunting effect. These results demonstrate a novel role for tonic inhibition in central auditory information processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.