ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Interplay of chemical neurotransmitters regulates developmental increase in electrical synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Antidepressant effects of fluoxetine: upregulation of connexin 36 and 43 in the hippocampus, prefrontal cortex, and amygdala.Molecular biology reports · 2025Article
- Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Function and Plasticity of Electrical Synapses in the Mammalian Brain: Role of Non-Junctional Mechanisms.Biology · 2022Review
- Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex.Frontiers in neuroanatomy · 2022Article
- Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions.Neuroscience · 2021Review
- Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance.Frontiers in aging neuroscience · 2021Article
- The interplay between electrical and chemical synaptogenesis.Journal of neurophysiology · 2018Review
- Protein Kinase C Enhances Electrical Synaptic Transmission by Acting on Junctional and Postsynaptic CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A potential role for neuronal connexin 36 in the pathogenesis of amyotrophic lateral sclerosis.Neuroscience letters · 2018Article
- Neuroprotective effects of leonurine against oxygen-glucose deprivation by targeting Cx36/CaMKII in PC12 cells.PloS one · 2018Article
- Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.BMC cell biology · 2017Review
- Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?Cellular and molecular life sciences : CMLS · 2015Review
- Connexins in neurons and glia: targets for intervention in disease and injury.Neural regeneration research · 2015Review
- Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin.PloS one · 2015Article
- Gap junctions in developing thalamic and neocortical neuronal networks.Cerebral cortex (New York, N.Y. : 1991) · 2014Review
- The ever-changing electrical synapse.Current opinion in neurobiology · 2014Review
- Neuronal gap junction coupling as the primary determinant of the extent of glutamate-mediated excitotoxicity.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Traumatic brain injury in vivo and in vitro contributes to cerebral vascular dysfunction through impaired gap junction communication between vascular smooth muscle cells.Journal of neurotrauma · 2014Article
- Electrical synapses and their functional interactions with chemical synapses.Nature reviews. Neuroscience · 2014Review
- Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons.Frontiers in neural circuits · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Coupling of neurons by electrical synapses (gap junctions) transiently increases in the mammalian CNS during development. We report here that the developmental increase in neuronal gap junction coupling and expression of connexin 36 (Cx36; neuronal gap junction protein) are regulated by an interplay between the activity of group II metabotropic glutamate receptors (mGluRs) and GABA(A) receptors. Specifically, using dye coupling, electrotonic coupling, Western blots and small interfering RNA in the rat and mouse hypothalamus and cortex in vivo and in vitro, we demonstrate that activation of group II mGluRs augments, and inactivation prevents, the developmental increase in neuronal gap junction coupling and Cx36 expression. However, changes in GABA(A) receptor activity have the opposite effects. The regulation by group II mGluRs is via cAMP/PKA-dependent signaling, and regulation by GABA(A) receptors is via Ca(2+)/PKC-dependent signaling. Furthermore, the receptor-mediated upregulation of Cx36 requires a neuron-restrictive silencer element in the Cx36 gene promoter, and the downregulation involves the 3'-untranslated region of the Cx36 mRNA, as shown using reverse-transcription quantitative real-time PCR and luciferase reporter activity analysis. In addition, the methyl thiazolyl tetrazolium analysis indicates that mechanisms for the developmental increase in neuronal gap junction coupling directly control the death/survival mechanisms in developing neurons. Together, the results suggest a multitiered strategy for chemical synapses in developmental regulation of electrical synapses.
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