Evidence map›Paper›PMID 21508162›Full record

ArticleClinical and vaccine immunology : CVI2011

Identification of false-positive syphilis antibody results using a semiquantitative algorithm.

Belinda Yen-Lieberman, Juliet Daniel, Cathy Means, Joan Waletzky, Thomas M Daly

Abstract read
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Sexually Transmitted Infections Treatment Guidelines, 2021.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  2. The Traditional or Reverse Algorithm for Diagnosis of Syphilis: Pros and Cons.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Pooled it
  3. Review
  4. Article
  5. Review
  6. CDC Laboratory Recommendations for Syphilis Testing, United States, 2024.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Belinda Yen-LiebermanSection of Immunopathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Juliet Daniel
Cathy Means
Joan Waletzky
Thomas M Daly

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Screening patients for syphilis serology using a "treponemal assay-first" approach presents unique challenges, particularly when applied to low-prevalence populations. The use of a screening algorithm that incorporates semiquantitative values from treponemal antibody test results can help to identify potential false-positive results while requiring a minimum of repeat testing.

Indexed as

False Positive ReactionsAntibodies, BacterialClinical Laboratory TechniquesHumansMass ScreeningSerologic TestsSyphilisAntibodies, Bacterial

Identifiers

PMID21508162
PMCPMC3122602

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.