ArticleThe Journal of clinical endocrinology and metabolism2011
Nine days of intensive exercise training improves mitochondrial function but not insulin action in adult offspring of mothers with type 2 diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Pilot study: an acute bout of high intensity interval exercise increases 12.5 h GH secretion.Physiological reports · 2018Trial
- Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans.Cell metabolism · 2017Trial
- A single nucleotide polymorphism associates with the response of muscle ATP synthesis to long-term exercise training in relatives of type 2 diabetic humans.Diabetes care · 2012Trial
- High-intensity aerobic, but not resistance or combined, exercise training improves both cardiometabolic health and skeletal muscle mitochondrial dynamics.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Article
- The mitochondrial profile in women with polycystic ovary syndrome: impact of exercise.Journal of molecular endocrinology · 2022Review
- Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males.Science advances · 2021Article
- The effects of two iso-volume endurance training protocols on mitochondrial dysfunction in type 2 diabetic male mice.Journal of diabetes and metabolic disorders · 2020Article
- Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?International journal of molecular sciences · 2020Review
- Metabolic flexibility is impaired in response to acute exercise in the young offspring of mothers with type 2 diabetes.Physiological reports · 2019Article
- Altered mitochondrial function in insulin-deficient and insulin-resistant states.The Journal of clinical investigation · 2018Review
- Training-Induced Changes in Mitochondrial Content and Respiratory Function in Human Skeletal Muscle.Sports medicine (Auckland, N.Z.) · 2018Review
- Very Low Volume High-Intensity Interval Exercise Is More Effective in Young Than Old Women.BioMed research international · 2018Article
- Article
- Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus.Nature reviews. Endocrinology · 2016Review
- Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice.Biological research · 2014Article
- The relationship between skeletal muscle mitochondrial citrate synthase activity and whole body oxygen uptake adaptations in response to exercise training.International journal of physiology, pathophysiology and pharmacology · 2014Article
- Postprandial improvement in insulin sensitivity after a single exercise session in adolescents with low aerobic fitness and physical activity.Pediatric diabetes · 2013Article
- Lactate and risk of incident diabetes in a case-cohort of the atherosclerosis risk in communities (ARIC) study.PloS one · 2013Article
- Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice.PloS one · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
contextA close association between insulin resistance and reduced skeletal muscle oxidative capacity has been reported in adult offspring of people with type 2 diabetes (T2D), prompting a hypothesis that insulin resistance may result from mitochondrial dysfunction or vice versa.
objectiveWe determined whether 9 d of intensive exercise training ameliorates the mitochondrial dysfunction and insulin resistance in offspring of T2D.
methodsWe compared the response to 9 d of intensive exercise training in eight (seven females, one male) healthy adult offspring of mothers with T2D with eight (six females, two males) nondiabetic controls. Skeletal muscle mitochondrial ATP production was assessed using a luciferase-based assay, and insulin sensitivity was measured using hyperinsulinemic-euglycemic clamps.
resultsShort-term intensive training increased skeletal muscle mitochondrial ATP production and citrate synthase activity similarly in both groups (P < 0.01). In contrast, whereas short-term intensive training reduced the fasting glucose (~5%, P = 0.035) and insulin levels (~40%, P = 0.011) as well as increased the glucose infusion rate during the hyperinsulinemic-euglycemic clamp (~50%, P = 0.028) among controls, no changes in these parameters were observed among offspring except for an increase in fasting glucose (~7%, P = 0.004).
conclusionA short-term intensive exercise training program was equally effective at increasing skeletal muscle oxidative capacity in nondiabetic people and in the offspring of mothers with diabetes. In contrast, the exercise improved insulin sensitivity only in nondiabetic people but not in the offspring of T2D mothers, revealing dissociation between improvements in skeletal muscle mitochondrial function and insulin sensitivity. The exercise effect on mitochondrial function and insulin sensitivity seems to be mediated by different regulatory pathways.
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