ArticleHaematologica2011
Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors.
Article in Haematologica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 96 citations in OpenAlex.
- The effect of high-dose vitamin D supplementation on hepcidin-25 and erythropoiesis in patients with chronic kidney disease.BMC nephrology · 2023Trial
- Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia.The Lancet. Global health · 2019Trial
- Plasma hepcidin is associated with future risk of venous thromboembolism.Blood advances · 2018Trial
- Effect of iron supplementation during lactation on maternal iron status and oxidative stress: A randomized controlled trial.Maternal & child nutrition · 2017Trial
- Serum Hepcidin Concentrations Decline during Pregnancy and May Identify Iron Deficiency: Analysis of a Longitudinal Pregnancy Cohort in The Gambia.The Journal of nutrition · 2017Trial
- A double blind randomised controlled trial comparing standard dose of iron supplementation for pregnant women with two screen-and-treat approaches using hepcidin as a biomarker for ready and safe to receive iron.BMC pregnancy and childbirth · 2016Trial
- Effect of sequential versus standard Helicobacter pylori eradication therapy on the associated iron deficiency anemia in children.Indian journal of pharmacologyTrial
- Physiologically based serum hepcidin and ferritin thresholds identify similar onsets of iron-deficient erythropoiesis in adult blood donors.British journal of haematology · 2026Article
- Body Iron Store and its Association with Risk of First Episode of Spontaneous Lower Extremity Deep Vein Thrombosis/ Pulmonary Embolism: A Case-Control Study.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023Article
- The Effect of Long-Term Iron Chelator Therapy on Serum Levels of Hepcidin and Ferritin in Patients with Thalassemia Major and Intermediate.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2022Article
- Role of Serum and Urinary Hepcidin in Young Females of Reproductive Age in North India.Journal of laboratory physicians · 2022Article
- A contemporary understanding of iron metabolism in active premenopausal females.Frontiers in sports and active living · 2022Review
- The association of iron deficiency anemia on chronic suppurative otitis media in children: A case-control study.Annals of medicine and surgery (2012) · 2021Article
- Baseline Hemoglobin, Hepcidin, Ferritin, and Total Body Iron Stores are Equally Strong Diagnostic Predictors of a Hemoglobin Response to 12 Weeks of Daily Iron Supplementation in Cambodian Women.The Journal of nutrition · 2021Article
- Hepcidin and GDF-15 are potential biomarkers of iron deficiency anaemia in chronic kidney disease patients in South Africa.BMC nephrology · 2020Article
- Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors.The journal of applied laboratory medicine · 2020Article
- A possible role for hepcidin in the detection of iron deficiency in severely anaemic HIV-infected patients in Malawi.PloS one · 2020Article
- The diagnostic potential of the iron-regulatory hormone hepcidin.HemaSphere · 2019Article
- Iron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Rats.Nutrients · 2019Article
- Role of HAMP Genetic Variants on Pathophysiology of Iron Deficiency Anemia.Indian journal of clinical biochemistry : IJCB · 2018Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCurrently used indicators of iron status have limitations. Hepcidin, a key regulator of iron metabolism, is reduced in iron deficiency. We sought to determine the properties of hepcidin as a diagnostic test of iron deficiency. DESIGN AND
methodsSera from female, non-anemic, whole blood donors were analyzed for hepcidin (enzyme-linked immunosorbent assay), ferritin, soluble transferrin receptor and C-reactive protein. Iron deficiency was defined as (i) serum ferritin less than 15 ng/mL or (ii) soluble transferrin receptor /log(ferritin) index greater than 3.2 if the C-reactive protein concentration was less than 10 mg/L, or greater than 2.2 if the C-reactive protein concentration was greater than 10 mg/L). Receiver operating characteristic curves were plotted to determine the overall utility and identify optimal cut-points of hepcidin as a test of iron deficiency.
resultsIn 261 blood donors the prevalence of iron deficiency defined by ferritin concentration was 59/261 [22.6% (17.5, 27.7)], whereas defined by soluble transferrin receptor/log(ferritin) index it was 53/261 [20.4% (15.4, 25.2)]. The 95% reference range of hepcidin concentration in the iron-replete population was 8.2-199.7 ng/mL. The area under the receiver operating characteristic curve for hepcidin compared with ferritin concentration less than 15 ng/mL was 0.87 (0.82, 0.92), while that compared with the soluble transferrin receptor /log(ferritin) index was 0.89 (95% CI 0.84, 0.93). For a diagnosis of iron deficiency defined by the soluble transferrin receptor/log(ferritin) index, hepcidin less than 8 ng/mL had a sensitivity of 41.5% and a specificity of 97.6%, while hepcidin less than 18 ng/mL had a sensitivity of 79.2% and a specificity of 85.6%.
conclusionsSerum hepcidin concentration may be a useful indicator of deficient iron stores. Further studies are required to evaluate the role of hepcidin in the diagnosis of iron deficiency in other groups of patients.
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