ArticleJournal of virology2011
T4-Like genome organization of the Escherichia coli O157:H7 lytic phage AR1.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Genomic characterization of three novel Shiga toxin-producing Escherichia coli lytic phages.Archives of virology · 2026Article
- Therapeutic Potential of a Novel Lytic Phage, vB_EclM_ECLFM1, against Carbapenem-ResistantInternational journal of molecular sciences · 2024Article
- Characterization of a lyticFrontiers in microbiology · 2023Article
- A NewMicroorganisms · 2022Article
- Article
- Characterization of a T4-like Bacteriophage vB_EcoM-Sa45lw as a Potential Biocontrol Agent for Shiga Toxin-Producing Escherichia coli O45 Contaminated on Mung Bean Seeds.Microbiology spectrum · 2022Article
- Characterization of polyvalentFrontiers in microbiology · 2022Article
- Genome Sequence of a T4-like Phage,Microbiology resource announcements · 2019Article
- Characterization of two polyvalent phages infecting Enterobacteriaceae.Scientific reports · 2017Article
- Bacteriophage application to control the contaminated water with Shigella.Scientific reports · 2016Article
- Article
- Complete Genome Sequence of Citrobacter freundii Myophage Moon.Genome announcements · 2015Article
- Genome organisation of the Acinetobacter lytic phage ZZ1 and comparison with other T4-like Acinetobacter phages.BMC genomics · 2014Article
- Differing populations of endemic bacteriophages in cattle shedding high and low numbers of Escherichia coli O157:H7 bacteria in feces.Applied and environmental microbiology · 2014Article
- Recognition of Protein-coding Genes Based on Z-curve Algorithms.Current genomics · 2014Article
- Complete Genome of Salmonella enterica Serovar Typhimurium Myophage Maynard.Genome announcements · 2013Article
- The host-range, genomics and proteomics of Escherichia coli O157:H7 bacteriophage rV5.Virology journal · 2013Article
- Complete genome sequence of T4-Like Escherichia coli bacteriophage HX01.Journal of virology · 2012Article
- Escherichia coli O157:H7 typing phage V7 is a T4-like virus.Journal of virology · 2012Article
- Characterization and comparative genomic analysis of a novel bacteriophage, SFP10, simultaneously inhibiting both Salmonella enterica and Escherichia coli O157:H7.Applied and environmental microbiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the genome organization and analysis of the first completely sequenced T4-like phage, AR1, of Escherichia coli O157:H7. Unlike most of the other sequenced phages of O157:H7, which belong to the temperate Podoviridae and Siphoviridae families, AR1 is a T4-like phage known to efficiently infect this pathogenic bacterial strain. The 167,435-bp AR1 genome is currently the largest among all the sequenced E. coli O157:H7 phages. It carries a total of 281 potential open reading frames (ORFs) and 10 putative tRNA genes. Of these, 126 predicted proteins could be classified into six viral orthologous group categories, with at least 18 proteins of the structural protein category having been detected by tandem mass spectrometry. Comparative genomic analysis of AR1 and four other completely sequenced T4-like genomes (RB32, RB69, T4, and JS98) indicated that they share a well-organized and highly conserved core genome, particularly in the regions encoding DNA replication and virion structural proteins. The major diverse features between these phages include the modules of distal tail fibers and the types and numbers of internal proteins, tRNA genes, and mobile elements. Codon usage analysis suggested that the presence of AR1-encoded tRNAs may be relevant to the codon usage of structural proteins. Furthermore, protein sequence analysis of AR1 gp37, a potential receptor binding protein, indicated that eight residues in the C terminus are unique to O157:H7 T4-like phages AR1 and PP01. These residues are known to be located in the T4 receptor recognition domain, and they may contribute to specificity for adsorption to the O157:H7 strain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.