ArticleThe Journal of biological chemistry2011
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia.Antioxidants (Basel, Switzerland) · 2021Article
- The Lipocalin2 Gene is Regulated in Mammary Epithelial Cells by NFκB and C/EBP In Response to Mycoplasma.Scientific reports · 2020Article
- Lipocalin 24p3 Induction in Colitis Adversely Affects Inflammation and Contributes to Mortality.Frontiers in immunology · 2019Article
- Endoplasmic reticulum stress drives proteinuria-induced kidney lesions via Lipocalin 2.Nature communications · 2016Article
- Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin.Clinical immunology (Orlando, Fla.) · 2014Article
- Adipokines as potential biomarkers in rheumatoid arthritis.Mediators of inflammation · 2014Article
- Lipocalin-2 (Lcn2) expression is mediated by maternal nutrition during the development of the fetal liver.Genes & nutrition · 2014Article
- Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Stress-induced lipocalin-2 controls dendritic spine formation and neuronal activity in the amygdala.PloS one · 2013Article
- Mechanisms of mammalian iron homeostasis.Biochemistry · 2012Review
- Mammalian siderophores, siderophore-binding lipocalins, and the labile iron pool.The Journal of biological chemistry · 2012Review
- Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin (NGAL)) receptor is expressed in distal nephron and mediates protein endocytosis.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
The lipocalin mouse 24p3 has been implicated in diverse physiological processes, including apoptosis, iron trafficking, development and innate immunity. Studies from our laboratory as well as others demonstrated the proapoptotic activity of 24p3 in a variety of cultured models. However, a general role for the lipocalin 24p3 in the hematopoietic system has not been tested in vivo. To study the role of 24p3, we derived 24p3 null mice and back-crossed them onto C57BL/6 and 129/SVE backgrounds. Homozygous 24p3(-/-) mice developed a progressive accumulation of lymphoid, myeloid, and erythroid cells, which was not due to enhanced hematopoiesis because competitive repopulation and recovery from myelosuppression were the same as for wild type. Instead, apoptotic defects were unique to many mature hematopoietic cell types, including neutrophils, cytokine-dependent mast cells, thymocytes, and erythroid cells. Thymocytes isolated from 24p3 null mice also displayed resistance to apoptosis-induced by dexamethasone. Bim response to various apoptotic stimuli was attenuated in 24p3(-/-) cells, thus explaining their resistance to the ensuing cell death. The results of these studies, in conjunction with those of previous studies, reveal 24p3 as a regulator of the hematopoietic compartment with important roles in normal physiology and disease progression. Interestingly, these functions are limited to relatively mature blood cell compartments.
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