ArticleCancer research2011
The death of the cancer cell.
Article in Cancer research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- The end of the genetic paradigm of cancer.PLoS biology · 2025Review
- The cancer puzzle: Welcome to organicism.Progress in biophysics and molecular biology · 2021Article
- Stromal Neutrophil Extracellular Trap Density Is an Independent Prognostic Factor for Cervical Cancer Recurrence.Frontiers in oncology · 2021Article
- A Novel Pyroptosis-Related Gene Signature for Early-Stage Lung Squamous Cell Carcinoma.International journal of general medicine · 2021Article
- Cancer associated fibroblast: Mediators of tumorigenesis.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- Over a century of cancer research: Inconvenient truths and promising leads.PLoS biology · 2020Article
- Unexpected Discoveries Should Be Reconsidered in Science-A Look to the Past?International journal of molecular sciences · 2019Article
- An Integrative Approach Toward Biology, Organisms, and Cancer.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Strategies of the War on Cancer: To Kill or to Neutralize?Frontiers in oncology · 2018Article
- Carcinogenesis explained within the context of a theory of organisms.Progress in biophysics and molecular biology · 2016Review
- Infiltrating T Cells Promote Bladder Cancer Progression via Increasing IL1→Androgen Receptor→HIF1α→VEGFa Signals.Molecular cancer therapeutics · 2016Article
- Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients.International immunology · 2016Review
- Decay Dynamics of Tumors.PloS one · 2016Article
- Screening for Chemical Contributions to Breast Cancer Risk: A Case Study for Chemical Safety Evaluation.Environmental health perspectives · 2015Review
- Cancer Metastases: So Close and So Far.Journal of the National Cancer Institute · 2015Article
- Cancer research in need of a scientific revolution: Using 'paradigm shift' as a method of investigation.Journal of biosciences · 2015Review
- Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.The Journal of biological chemistry · 2014Article
- Miniaturized pre-clinical cancer models as research and diagnostic tools.Advanced drug delivery reviews · 2014Review
- Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis?BioMed research international · 2014Review
- Improving anticancer efficacy of (-)-epigallocatechin-3-gallate gold nanoparticles in murine B16F10 melanoma cells.Drug design, development and therapy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
For a century, the perception that there are qualitative differences between a normal cell and a cell belonging to a tumor has dominated discussions aimed at explaining cancer. However, an analysis of the experimental evidence suggests that individual normal cells and individual cancer cells share the same two fundamental behavioral properties, namely, proliferation and motility. Each individual cancer cell carries no recognizable molecules or structures that make them consistently distinguishable from normal cells. Herein, we argue that the differences between normal and cancerous states are instead identifiable at the tissue level of biological organization, and therefore, the search for identification of a cancer cell should be abandoned.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.