ReviewTrends in genetics : TIG2011
Emerging patterns of epigenomic variation.
Review in Trends in genetics : TIG, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- The Future of Epigenetics: Emerging Technologies and Clinical Applications.ACS pharmacology & translational science · 2026Review
- Review
- The metagenomics worldwide research.Current genetics · 2017Review
- Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies.American journal of epidemiology · 2016Article
- Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk.Mutagenesis · 2015Review
- Uncovering correlated variability in epigenomic datasets using the Karhunen-Loeve transform.BioData mining · 2015Article
- Epigenetic contribution to individual variation in response to lipopolysaccharide in bovine dermal fibroblasts.Veterinary immunology and immunopathology · 2014Article
- Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation.Carcinogenesis · 2013Review
- The fate is not always written in the genes: epigenomics in epidemiologic studies.Environmental and molecular mutagenesis · 2013Review
- Epigenetics of progression of chronic kidney disease: fact or fantasy?Seminars in nephrology · 2013Review
- High natural gene expression variation in the reef-building coral Acropora millepora: potential for acclimative and adaptive plasticity.BMC genomics · 2013Article
- Predicting cell types and genetic variations contributing to disease by combining GWAS and epigenetic data.PloS one · 2013Article
- Concordance in hippocampal and fecal Nr3c1 methylation is moderated by maternal behavior in the mouse.Ecology and evolution · 2012Article
- Evaluation of single CpG sites as proxies of CpG island methylation states at the genome scale.Nucleic acids research · 2012Article
- Epigenetic mechanisms and the development of asthma.The Journal of allergy and clinical immunology · 2012Review
- Epigenetic polymorphism and the stochastic formation of differentially methylated regions in normal and cancerous tissues.Nature genetics · 2012Article
- Epigenomics of idiopathic pulmonary fibrosis.Epigenomics · 2012Review
- Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra.Current gerontology and geriatrics research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Fuelled by new sequencing technologies, epigenome mapping projects are revealing epigenomic variation at all levels of biological complexity, from species to cells. Comparisons of methylation profiles among species reveal evolutionary conservation of gene body methylation patterns, pointing to the fundamental role of epigenomes in gene regulation. At the human population level, epigenomic changes provide footprints of the effects of genomic variants within the vast nonprotein-coding fraction of the genome, and comparisons of the epigenomes of parents and their offspring point to quantitative epigenomic parent-of-origin effects confounding classical Mendelian genetics. At the organismal level, comparisons of epigenomes from diverse cell types provide insights into cellular differentiation. Finally, comparisons of epigenomes from monozygotic twins help dissect genetic and environmental influences on human phenotypes and longitudinal comparisons reveal aging-associated epigenomic drift. The development of new bioinformatic frameworks for comparative epigenome analysis is putting epigenome maps within the reach of researchers across a wide spectrum of biological disciplines.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.