ArticleBMC genetics2011
The distal end of porcine chromosome 6p is involved in the regulation of skatole levels in boars.
Article in BMC genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Genomic background and genetic relationships between boar taint and fertility traits in German Landrace and Large White.BMC genetics · 2020Article
- Genomic analysis reveals genes affecting distinct phenotypes among different Chinese and western pig breeds.Scientific reports · 2018Article
- Fine mapping of a QTL affecting levels of skatole on pig chromosome 7.BMC genetics · 2017Article
- Differential expression and co-expression gene networks reveal candidate biomarkers of boar taint in non-castrated pigs.Scientific reports · 2017Article
- Genome-wide association analyses using a Bayesian approach for litter size and piglet mortality in Danish Landrace and Yorkshire pigs.BMC genomics · 2016Article
- Exploring evidence of positive selection reveals genetic basis of meat quality traits in Berkshire pigs through whole genome sequencing.BMC genetics · 2015Article
- Genome-wide association analyses for boar taint components and testicular traits revealed regions having pleiotropic effects.BMC genetics · 2015Article
- Analysis of the genetics of boar taint reveals both single SNPs and regional effects.BMC genomics · 2014Article
- Genome-wide association studies identify the loci for 5 exterior traits in a Large White × Minzhu pig population.PloS one · 2014Article
- Identification of the novel candidate genes and variants in boar liver tissues with divergent skatole levels using RNA deep sequencing.PloS one · 2013Article
- A missense mutation (c.1963A<G) of the complementary component 2 (C2) gene is associated with serum Ca⁺⁺ concentrations in pigs.Molecular biology reports · 2012Article
- Progress of genome wide association study in domestic animals.Journal of animal science and biotechnology · 2012Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoar taint is an unpleasant condition of pork, mainly due to the accumulation of androstenone and skatole in male pigs at onset of puberty. This condition is the cause of considerable economic losses in the pig industry and the most common practice to control it is to castrate male piglets. Because of the economic and animal welfare concerns there is interest in developing genetic markers that could be used in selection schemes to decrease the incidence of boar taint. The Porcine 60 K SNP Beadchip was used to genotype 891 pigs from a composite Duroc sire line, for which skatole levels in fat had been collected.
resultsThe genome-wide association study revealed that 16 SNPs (single nucleotide polymorphisms) located on the proximal region of chromosome 6 were significantly associated with skatole levels. These SNPs are grouped in three separate clusters located in the initial 6 Mb region of chromosome 6. The differences observed between the homozygote genotypes for SNPs in the three clusters were substantial, including a difference of 102.8 ng/g skatole in melted fat between the homozygotes for the ALGA0107039 marker. Single SNPs explain up to 22% of the phenotypic variance. No obvious candidate genes could be pinpointed in the region, which may be due to the need of further annotation of the pig genome.
conclusionsThis study demonstrated new SNP markers significantly associated with skatole levels in the distal region of chromosome 6p. These markers defined three independent clusters in the region, which contain a low number of protein-coding genes. The considerable differences observed between the homozygous genotypes for several SNPs may be used in future selection schemes to reduce skatole levels in pigs.
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