ArticleCell communication and signaling : CCS2011
Macroscopic law of conservation revealed in the population dynamics of Toll-like receptor signaling.
Article in Cell communication and signaling : CCS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Metabolomics and modelling approaches for systems metabolic engineering.Metabolic engineering communications · 2022Review
- Systems biology approaches integrated with artificial intelligence for optimized metabolic engineering.Metabolic engineering communications · 2020Review
- Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities.Frontiers in immunology · 2015Review
- Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms.Journal of mathematical biology · 2014Article
- Systems Biology Strategy Reveals PKCδ is Key for Sensitizing TRAIL-Resistant Human Fibrosarcoma.Frontiers in immunology · 2014Article
- Parameter-less approaches for interpreting dynamic cellular response.Journal of biological engineering · 2014Article
- A systems biology approach to suppress TNF-induced proinflammatory gene expressions.Cell communication and signaling : CCS · 2013Article
- Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses.American journal of clinical and experimental immunology · 2013Review
- The recognition of chaos in host-pathogen response.Frontiers in physiology · 2012Article
- Is central dogma a global property of cellular information flow?Frontiers in physiology · 2012Article
- Mathematical and statistical modeling in cancer systems biology.Frontiers in physiology · 2012Article
- Finding Self-organization from the Dynamic Gene Expressions of Innate Immune Responses.Frontiers in physiology · 2012Article
- Enhancing apoptosis in TRAIL-resistant cancer cells using fundamental response rules.Scientific reports · 2011Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stimulating the receptors of a single cell generates stochastic intracellular signaling. The fluctuating response has been attributed to the low abundance of signaling molecules and the spatio-temporal effects of diffusion and crowding. At population level, however, cells are able to execute well-defined deterministic biological processes such as growth, division, differentiation and immune response. These data reflect biology as a system possessing microscopic and macroscopic dynamics. This commentary discusses the average population response of the Toll-like receptor (TLR) 3 and 4 signaling. Without requiring detailed experimental data, linear response equations together with the fundamental law of information conservation have been used to decipher novel network features such as unknown intermediates, processes and cross-talk mechanisms. For single cell response, however, such simplicity seems far from reality. Thus, as observed in any other complex systems, biology can be considered to possess order and disorder, inheriting a mixture of predictable population level and unpredictable single cell outcomes.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.