ArticleScandinavian journal of trauma, resuscitation and emergency medicine2011
High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis.Surgical endoscopy · 2017Pooled it
- Circulatory HMGB1 is an early predictive and prognostic biomarker of ARDS and mortality in a swine model of polytrauma.Frontiers in immunology · 2023Article
- A Focus on Intra-Abdominal Sepsis with Biomarkers: A Literature Review.The Eurasian journal of medicine · 2022Article
- The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic.Immunity, inflammation and disease · 2021Review
- High Mobility Group box-1 (HMGB1) Protein As a Biomarker for Acute Cholecystitis.Reports of biochemistry & molecular biology · 2019Article
- The Place of Calprotectin, Lactoferrin, and High-Mobility Group Box 1 Protein on Diagnosis of Acute Appendicitis with Children.The Indian journal of surgery · 2017Article
- Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases.Disease markers · 2017Article
- Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference.World journal of emergency surgery : WJES · 2017Review
- Inflammatory mediators in intra-abdominal sepsis or injury - a scoping review.Critical care (London, England) · 2015Article
- HMGB1 in health and disease.Molecular aspects of medicine · 2014Review
- High-mobility group box 1 (HMGB1) in childhood: from bench to bedside.European journal of pediatrics · 2014Review
- The spectrum of anti-chromatin/nucleosome autoantibodies: independent and interdependent biomarkers of disease.Journal of immunology research · 2014Review
- Evaluation of high mobility group box 1 protein as a presurgical diagnostic marker reflecting the severity of acute appendicitis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2012Article
- The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?Scandinavian journal of trauma, resuscitation and emergency medicine · 2011Article
- A review of the predictive role of plasma d-lactate level in acute appendicitis: a myth or truth?ISRN toxicology · 2011Article
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7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this prospective study was therefore to evaluate the diagnostic value of preoperative serum High Mobility Group Box Protein-1 (HMGB-1) levels in patients with Acute Appendicitis (AA) who show normal white blood cell count (WBC) counts.
methodOur study was carried out from October 2010 through November 2010 and included 20 healthy control group participants and 60 patients who presented at the emergency department of Erzurum Training and Research Hospital in Turkey with acute abdominal pain complaints, who were pathologically diagnosed with AA after laparotomy, and who agreed to participate in the study.
resultsOf the 60 patients who underwent appendectomies, 36 were male and 24 were female, and of the healthy group, 12 were male and 8 female. The age averages of the patients in Groups 1, 2 and 3 were, respectively, 31.3+15.4, 34.0+16.3 and 31.0+13.1 years. The WBC averages of Groups 1, 2 and 3 were, respectively, 7.41+2.02 (x10⁹/L), 15.71+2.85 (x10⁹/L) and 8.51+1.84 (x10⁹/L). The HMGB-1 levels for Groups 1 (healthy persons), 2 (AA patients with high WBC counts ) and 3 (AA patients with normal WBC counts) were, respectively, 21.71±11.36, 37.28+13.37 and 36.5±17.73 ng/ml. The average HMGB-1 level of the patients with AA was 36.92±15.43 ng/ml while the average HMGB-1 value of the healthy group was 21.71±11.36 ng/ml.
conclusionThe significantly higher levels of HMGB-1 in AA patients compared to healthy persons infer that HMGB-1 might be useful in the diagnosis of AA. Use of HMGB-1, especially in patients with normal WBC counts, will reduce the number of unnecessary explorations.
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